Dlc1^Gt(XE082)Byg
Gene trapped Allele Detail

Summary

• Symbol: Dlc1^Gt(XE082)Byg
• Name: deleted in liver cancer 1; gene trap XE082, BayGenomics
• MGI ID: MGI:4124985
• Gene: Dlc1 Location: Chr8:37034905-37420297 bp, - strand Genetic Position: Chr8, 23.05 cM, cytoband A4-B2
• Alliance: Dlc1^Gt(XE082)Byg page

Yolk sac and neural tube abnormalities in Dlc1^Gt(XE082)Byg/Dlc1^Gt(XE082)Byg embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: XE082
• Germline Transmission: Earliest citation of germline transmission: J:189950
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector inserted into intron 1. Western blot analysis confirmed reduced protein expression of the protein product of the 6.1 kb transcript. (J:189950)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XE082	CC178327 ; (MGI Seq Detail)	5' RACE	Chr8:37080712-37081061 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  200 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Dlc1^Gt(XE082)Byg allele

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dlc1^Gt(XE082)Byg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlc1 Mutation: 227 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)