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Ppm1bGt(AW0406)Wtsi
Gene trapped Allele Detail
Summary
Symbol: Ppm1bGt(AW0406)Wtsi
Name: protein phosphatase 1B, magnesium dependent, beta isoform; gene trap AW0406, Wellcome Trust Sanger Institute
MGI ID: MGI:3857220
Synonyms: Ppm1bd
Gene: Ppm1b  Location: Chr17:85264169-85331419 bp, + strand  Genetic Position: Chr17, 55.13 cM, cytoband E4-E5
Alliance: Ppm1bGt(AW0406)Wtsi page
Mutation
origin
Mutant Cell Line:  AW0406
Germline Transmission:  Earliest citation of germline transmission: J:243815
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Sanger Inst. Gene Trap Res.
Mutation
description
Allele Type:    Gene trapped (Hypomorph, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0lxr
 
Mutation detailsThe lacZ and neomycin resistance genes containing gene trap vector inserted into intron 2 of the host gene. Transcrips from this allele will code for a fusion protein of the first 282 amino-acids of the host gene (which excludes the functional phosphatase domain), followed by beta-galactosidase and neo. Immunoblots show that a small amount of the wildtype L- and S-variants of the host gene peptides are still produced, possibly owing to splicing out of trap-containing intron 2. (J:243815)
Sequence Tags: 
Sequence tag details (1 tag)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppm1b Mutation:  38 strains or lines available
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory