Phenotypes associated with this allele

• Allele Symbol: Ppm1b^{Gt(AW0406)Wtsi}
• Allele Name: gene trap AW0406, Wellcome Trust Sanger Institute
• Allele ID: MGI:3857220
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppm1b^Gt(AW0406)Wtsi/Ppm1b^Gt(AW0406)Wtsi	B6.129P2-Ppm1b^Gt(AW0406)Wtsi	MGI:6111451
cx2	Ppm1b^Gt(AW0406)Wtsi/Ppm1b^Gt(AW0406)Wtsi Ripk3^tm1Vmd/Ripk3^tm1Vmd	B6.129-Ripk3^tm1Vmd Ppm1b^Gt(AW0406)Wtsi	MGI:6111453

Genotype
MGI:6111451

hm1

• Allelic Composition: Ppm1b^{Gt(AW0406)Wtsi}/Ppm1b^{Gt(AW0406)Wtsi}
• Genetic Background: B6.129P2-Ppm1b^{Gt(AW0406)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell death ( J:243815 )

• increased necroptosis in caecum after intravenous injection with mouse Tnf

• increased TNF-induced Ripk3 phosphorylation

mortality/aging

abnormal survival ( J:243815 )

• reduced survival rate after intravenous injection with mouse Tnf

• viable

reproductive system

reproductive system phenotype ( J:243815 )

N • pups born at normal Mendelian ratio after heterozygous mutant mating

Genotype
MGI:6111453

cx2

• Allelic Composition: Ppm1b^{Gt(AW0406)Wtsi}/Ppm1b^{Gt(AW0406)Wtsi}; Ripk3^tm1Vmd/Ripk3^tm1Vmd
• Genetic Background: B6.129-Ripk3^tm1Vmd Ppm1b^{Gt(AW0406)Wtsi}

cellular

cellular phenotype ( J:243815 )

N • normal resistance to necroptosis in caecum after intravenous injection with mouse Tnf