Hprt1^tm2(AGT)Asku
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm2(AGT)Asku
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Ashok Kumar
• MGI ID: MGI:3832669
• Synonyms: AG haplotype
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm2(AGT)Asku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143791
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^tm2(AGT)Asku expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AGT (183)

  Agt	(MGI:87963)

• Mutation details: The complete 13.5kb human AGT genomic sequence from an AG haplotype individual was inserted upstream of the Hprt locus in BK4 ES cells. The AG haplotype contains the following nucleotides at the positions indicated: -6A, -20A, -217G, -532C, -793G, -1074G. The insertion vector also restored part of the Hprt promoter and exon regions that are missing in BK4 ES cells. (J:143791)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1273 strains or lines available

References

• Original: J:143791 Jain S, et al., A haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G. Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1849-57
• All: 1 reference(s)