All Phenotypes Hprt1<tm2(AGT)Asku> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^tm2(AGT)Asku
targeted mutation 2, Ashok Kumar
MGI:3832669

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hprt1^tm2(AGT)Asku/Y Tg(REN)64071Sig/?	involves: 129P2/OlaHsd * C57BL/6	MGI:3832678

Allelic Composition	Hprt1^tm2(AGT)Asku/Y Tg(REN)64071Sig/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^tm2(AGT)Asku mutation (0 available); any Hprt1 mutation (1274 available)
Tg(REN)64071Sig mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating angiotensin II level ( J:143791 )

• plasma levels of angiotensin II are increased 40% over non-transgenic controls

abnormal protein level ( J:143791 )

• liver levels of angiotensinogen are lower than mice of the AA haplotype

• kidney levels of angiotensinogen are lower than mice of the AA haplotype

abnormal circulating angiotensinogen level ( J:143791 )

• plasma levels are less than in mice of the AG haplotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:143791 )

• blood pressure in males measured at 3 months of age is 117mm Hg compared to 111mm Hg in non-transgenic controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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