Hs6st1tm1.1Wvc
Targeted Allele Detail
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Symbol: |
Hs6st1tm1.1Wvc |
Name: |
heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1.1, Wellington V Cardoso |
MGI ID: |
MGI:3793787 |
Synonyms: |
Hs6st1- |
Gene: |
Hs6st1 Location: Chr1:36107481-36145527 bp, + strand Genetic Position: Chr1, 15.15 cM, cytoband B
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Alliance: |
Hs6st1tm1.1Wvc page
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Decrease in weight and survival of Hs6st1tm1.1Wvc/Hs6st1tm1.1Wvc mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:135241
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted |
Mutation: |
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Intragenic deletion
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Mutation details: Germ line, cre mediated recombination was used to remove exon 1, which contains the start methionine codon and encodes the PAPs binding domain. RT-PCR confirmed weak expression of the truncated transcript that encodes a protein expected to have little enzymatic activity.
(J:135241)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hs6st1 Mutation: |
26 strains or lines available
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Original: |
J:135241 Izvolsky KI, et al., Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan;46(1):8-18 |
All: |
1 reference(s) |
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