Phenotypes associated with this allele

• Allele Symbol: Hs6st1^tm1.1Wvc
• Allele Name: targeted mutation 1.1, Wellington V Cardoso
• Allele ID: MGI:3793787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hs6st1^tm1.1Wvc/Hs6st1^tm1.1Wvc	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	MGI:3795681

Genotype
MGI:3795681

hm1

• Allelic Composition: Hs6st1^tm1.1Wvc/Hs6st1^tm1.1Wvc
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in weight and survival of Hs6st1^tm1.1Wvc/Hs6st1^tm1.1Wvc mice

mortality/aging

decreased survivor rate ( J:135241 )

• only 70% of mice survive beyond weaning

postnatal lethality, incomplete penetrance ( J:135241 )

• only 70% of mice survive beyond weaning

prenatal lethality, incomplete penetrance ( J:135241 )

• fewer than expected mice are born

growth/size/body

decreased body weight ( J:135241 )

• by 3 weeks of age, some mice exhibit decreased body weight compared to in wild-type mice

postnatal growth retardation ( J:135241 )

• in some mice

respiratory system

overexpanded pulmonary alveolus ( J:135241 )

• mice that die prior to weaning exhibit enlarged alveolar space