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Del(2Hoxd4-Hoxd13)28Ddu
Targeted Allele Detail
Summary
Symbol: Del(2Hoxd4-Hoxd13)28Ddu
Name: deletion, Chr 2, Denis Duboule 28
MGI ID: MGI:3762137
Synonyms: CreDel7, Del28Ddu, Hoxdd11CreDel7
Gene: Del(2Hoxd4-Hoxd13)28Ddu  Location: Chr2:74498654-74559504 bp  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82530
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Intergenic deletion, Intragenic deletion
  Del(2Hoxd4-Hoxd13)28Ddu involves 11 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
 
Mutation detailsThese mice were generated by producing animals carrying the Evx2/Hoxd1tm4Ddu allele and another targeted Hoxd allele Del(2Hoxd4-Hoxd13)30Ddu which lacks Hoxd4-Hoxd13 and has a Hoxd11/lacZ fusion gene upstream of Hoxd3 with a single loxP site between the two loci. Cre recombinase was introduced via the Tg(Sycp1-cre)4Min transgene, resulting in a crossing over between the loxP sites in the two alleles during meiotic prophase, inducing deletion of Hoxd3 to Hoxd13, as well as the Hoxd11/lacZ fusion gene. (J:82530)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(2Hoxd4-Hoxd13)28Ddu Mutation:  1 strain or line available
References
Original:  J:82530 Herault Y, et al., A nested deletion approach to generate Cre deleter mice with progressive Hox profiles. Int J Dev Biol. 2002;46(1 Spec No):185-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory