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Targeted Allele Detail
Symbol: Evx2/Hoxd13tm4(cre)Ddu
Name: even-skipped homeobox 2; targeted mutation 4, Denis Duboule
MGI ID: MGI:3762124
Synonyms: CreDel0, Hoxd11/Cre, HoxDd11Cre, HoxDd11CreDel0
Gene: Evx2  Location: Chr2:74483335-74489901 bp, - strand  Genetic Position: Chr2, 44.13 cM
Alliance: Evx2/Hoxd13tm4(cre)Ddu page
Germline Transmission:  Earliest citation of germline transmission: J:82530
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Evx2/Hoxd13tm4(cre)Ddu expression driven by 1 gene
Mutation detailsA mouse Hoxd11 trangene construct was modified by in-frame insertion of the Cre coding sequence, followed by the SV40 polyadenylation signal, at the start codon in exon 1 so that Cre recombinase is expressed under control of the Hoxd11 regulatory elements, but without any residues derived from Hoxd11. Homology arms were added to target integration to a site between Hoxd13 and Evx2, at the 5' extremity of the cluster. (J:82530)
 Tissue activity of this recombinase allele
Driver: Hoxd11 (mouse)
Summary of all recombinase alleles driven by Hoxd11.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Evx2 Mutation:  19 strains or lines available
Original:  J:82530 Herault Y, et al., A nested deletion approach to generate Cre deleter mice with progressive Hox profiles. Int J Dev Biol. 2002;46(1 Spec No):185-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory