Ar^tm1Fcl
Targeted Allele Detail

Summary

• Symbol: Ar^tm1Fcl
• Name: androgen receptor; targeted mutation 1, Frank Claessens
• MGI ID: MGI:3706240
• Synonyms: SPARKI
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm1Fcl page

Histochemical analysis of wild type and Ar^tm1Fcl/Y testes

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120102
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The second zinc-finger of the locus, encoded by exon 3, was replaced by exon 4 of the nuclear receptor subfamily 3, group C, member 1, resulting in a chimeric protein. A floxed neo was included in the vector downstream of the exon substitution and was subsequently removed via cre mediated recombination. (J:120102)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 22 strains or lines available

References

• Original: J:120102 Schauwaers K, et al., Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4961-6
• All: 4 reference(s)