Analysis Tools
normal phenotype
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• female homozygotes are viable and fertile
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Allele Symbol Allele Name Allele ID |
Artm1Fcl targeted mutation 1, Frank Claessens MGI:3706240 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female homozygotes are viable and fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Histochemical analysis of wild type and Artm1Fcl/Y testes
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• total number of germ cells is reduced to 55% that of controls
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• total number of germ cells is reduced to 55% that of controls
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• anterior prostate weight is 67% of wild-type weight at 11 weeks of age
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• ventral prostate weight is reduced to 54% of wild-type weight at 11 weeks of age
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• seminal vesicles are reduced to 55% of wild-type weight at 11 weeks of age
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• total number of Sertoli cells is reduced to 68% of controls (expressed as nuclear volume/testis)
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• seminiferous tubules have reduced diameters (~85% of wild-type)
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• testis weight is reduced to 67% of wild-type at 11 weeks of age
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• weight is reduced to 56% of wild-type weight at 11 weeks of age
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• litters sired by mutant males are reduced 2-fold in size and 4-fold in frequency
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• males display reduced fertility based upon decreased litter size and frequency
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• anterior prostate weight is 67% of wild-type weight at 11 weeks of age
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• ventral prostate weight is reduced to 54% of wild-type weight at 11 weeks of age
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• seminal vesicles are reduced to 55% of wild-type weight at 11 weeks of age
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• total number of Sertoli cells is reduced to 68% of controls (expressed as nuclear volume/testis)
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• seminiferous tubules have reduced diameters (~85% of wild-type)
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• testis weight is reduced to 67% of wild-type at 11 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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