About   Help   FAQ
Unc79Lwt
Chemically induced Allele Detail
Summary
Symbol: Unc79Lwt
Name: unc-79 homolog; lightweight
MGI ID: MGI:3701691
Synonyms: Unc79Lwt, Unc79Mlca3
Gene: Unc79  Location: Chr12:102915118-103150324 bp, + strand  Genetic Position: Chr12, 52.68 cM
Alliance: Unc79Lwt page
Mutation
origin
Strain of Origin:  DBA/2J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThe dominant behavioral phenotype of one of the independent loci, Lightweight (Lwt), results from a nonsense mutation in the mouse homolog of the C. elegans unc-79 gene. The mutation results in a G-T transversion at amino acid position 1292 leading to the conversion of a glutamic acid residue to a premature stop codon in exon 27. Immunoblot analysis indicates an absence of the expected band at 290 kDa in mutant versus wildtype homogenates. (J:118059)
Inheritance:    Dominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Unc79 Mutation:  80 strains or lines available
References
Original:  J:118059 Speca DJ, et al., A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice. Genes Brain Behav. 2006 Feb;5(1):19-28
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/24/2023
MGI 6.22
The Jackson Laboratory