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Chemically induced Allele Detail
Symbol: Unc79Lwt
Name: unc-79 homolog; lightweight
MGI ID: MGI:3701691
Synonyms: Unc79Lwt, Unc79Mlca3
Gene: Unc79  Location: Chr12:102915118-103150324 bp, + strand  Genetic Position: Chr12, 52.68 cM
Alliance: Unc79Lwt page
Strain of Origin:  DBA/2J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThe dominant behavioral phenotype of one of the independent loci, Lightweight (Lwt), results from a nonsense mutation in the mouse homolog of the C. elegans unc-79 gene. The mutation results in a G-T transversion at amino acid position 1292 leading to the conversion of a glutamic acid residue to a premature stop codon in exon 27. Immunoblot analysis indicates an absence of the expected band at 290 kDa in mutant versus wildtype homogenates. (J:118059)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Unc79 Mutation:  80 strains or lines available
Original:  J:118059 Speca DJ, et al., A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice. Genes Brain Behav. 2006 Feb;5(1):19-28
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory