Fbxl3^Afh
Chemically induced Allele Detail

Summary

• Symbol: Fbxl3^Afh
• Name: F-box and leucine-rich repeat protein 3; after hours
• MGI ID: MGI:3687377
• Synonyms: Afh, PLAY68
• Gene: Fbxl3 Location: Chr14:103317675-103337002 bp, - strand Genetic Position: Chr14, 51.73 cM, cytoband E2.2
• Alliance: Fbxl3^Afh page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: This mutation, discovered in an ENU mutagenesis screen for behavioral phenotypes, is a missense mutation in exon 5 that results in substitution of serine for cysteine at amino acid 358. (J:121578)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fbxl3 Mutation: 41 strains or lines available

References

• Original: J:121578 Godinho SI, et al., The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science. 2007 May 11;316(5826):897-900
• All: 9 reference(s)