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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxl3Afh
after hours
MGI:3687377
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxl3Afh/Fbxl3Afh involves: BALB/c * C3H/HeH MGI:3711662
ht2
 		Fbxl3Afh/Fbxl3+ involves: BALB/c * C3H/HeH MGI:3711663
ht3
 		Fbxl3Afh/Fbxl3+ involves: BALB/cOlaHsd * C3H/HeH MGI:3608425


Genotype
MGI:3711662
hm1
Allelic
Composition		 Fbxl3Afh/Fbxl3Afh
Genetic
Background		 involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3Afh mutation (2 available); any Fbxl3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
prolonged circadian behavior period ( J:121578 )
• period is very significantly lengthened (by ~3 hours) compared to wild-type, assessed by activity like wheel-running

nervous system
abnormal hypothalamus physiology ( J:121578 )
• suprachiasmatic nucleus molecular cycle period is lengthened in vitro




Genotype
MGI:3711663
ht2
Allelic
Composition		 Fbxl3Afh/Fbxl3+
Genetic
Background		 involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3Afh mutation (2 available); any Fbxl3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
prolonged circadian behavior period ( J:121578 )
• period is very significantly lengthened (by ~0.5-1 hour) compared to wild-type, assessed by activity like wheel-running

nervous system
abnormal hypothalamus physiology ( J:121578 )
• suprachiasmatic nucleus molecular cycle period is lengthened in vitro




Genotype
MGI:3608425
ht3
Allelic
Composition		 Fbxl3Afh/Fbxl3+
Genetic
Background		 involves: BALB/cOlaHsd * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3Afh mutation (2 available); any Fbxl3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
prolonged circadian behavior period ( J:101896 )
• the circadian period is 24.2 hours compared to 23.59 hours in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory