Rasa4^tm1Ywh
Targeted Allele Detail

Summary

• Symbol: Rasa4^tm1Ywh
• Name: RAS p21 protein activator 4; targeted mutation 1, You-Wen He
• MGI ID: MGI:3589205
• Synonyms: CAPRI^-
• Gene: Rasa4 Location: Chr5:136112770-136140714 bp, + strand Genetic Position: Chr5, 75.76 cM
• Alliance: Rasa4^tm1Ywh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100455
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5, the exon encoding amino acids 101-143, was replaced with a neomycin resistance cassette. Protein was not detected in mutant lymph nodes or macrophages by immunoblot analysis. (J:100455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasa4 Mutation: 34 strains or lines available

References

• Original: J:100455 Zhang J, et al., An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Nat Immunol. 2005 Sep;6(9):911-9
• All: 1 reference(s)