Phenotypes associated with this allele

• Allele Symbol: Rasa4^tm1Ywh
• Allele Name: targeted mutation 1, You-Wen He
• Allele ID: MGI:3589205
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasa4^tm1Ywh/Rasa4^tm1Ywh	B6.129S6-Rasa4^tm1Ywh	MGI:3590504

Genotype
MGI:3590504

hm1

• Allelic Composition: Rasa4^tm1Ywh/Rasa4^tm1Ywh
• Genetic Background: B6.129S6-Rasa4^tm1Ywh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage phagocytosis ( J:100455 )

• reduced formation of phagocytic cups

• 70% reduction in phagocytosis of S. pneumoniae and slightly reduced phagocytosis of H. influenzae

• defective Fc-gammaR mediated phagocytosis

increased susceptibility to bacterial infection ( J:100455 )

• 80% lethality 2 days after Salmonella typhimurium (gram -) infection at a dose that controls survived

• 60% lethality after Streptococcus pneumoniae (gram +) within 3 days of infection at a dose which controls survived, also massive inflammation of lungs and high levels of bacteria in lungs

• decreased clearance off Haemophilus influenzae and group B Streptococcus

hematopoietic system

impaired macrophage phagocytosis ( J:100455 )

• reduced formation of phagocytic cups

• 70% reduction in phagocytosis of S. pneumoniae and slightly reduced phagocytosis of H. influenzae

• defective Fc-gammaR mediated phagocytosis

cellular

impaired macrophage phagocytosis ( J:100455 )

• reduced formation of phagocytic cups

• 70% reduction in phagocytosis of S. pneumoniae and slightly reduced phagocytosis of H. influenzae

• defective Fc-gammaR mediated phagocytosis