St8sia4^tm1Crem
Targeted Allele Detail

Summary

• Symbol: St8sia4^tm1Crem
• Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; targeted mutation 1, Harold Cremer
• MGI ID: MGI:3582251
• Synonyms: St8sia-IV-, St8SiaIV^-
• Gene: St8sia4 Location: Chr1:95515407-95595296 bp, - strand Genetic Position: Chr1, 47.76 cM, cytoband D
• Alliance: St8sia4^tm1Crem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63481
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/neo cassette replaced approximately 2kb of gene starting 8 nucleotides upstream of the ATG start codon of the first exon and including 1.4 kb of intron 1 (encoding the cytosolic amino terminus and the transmembrane region). Northern blot analysis verified absence of expression. (J:63481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St8sia4 Mutation: 26 strains or lines available

References

• Original: J:63481 Eckhardt M, et al., Mice deficient in the polysialyltransferase ST8SiaIV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity. J Neurosci. 2000 Jul 15;20(14):5234-44
• All: 32 reference(s)