Crygs^tm1Gwis
Targeted Allele Detail

Summary

• Symbol: Crygs^tm1Gwis
• Name: crystallin, gamma S; targeted mutation 1, Graeme Wistow
• MGI ID: MGI:3522501
• Gene: Crygs Location: Chr16:22623953-22630160 bp, - strand Genetic Position: Chr16, 13.66 cM
• Alliance: Crygs^tm1Gwis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201031
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in lenses. (J:201031)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crygs Mutation: 42 strains or lines available

References

• Original: J:201031 Fan J, et al., A role for gammaS-crystallin in the organization of actin and fiber cell maturation in the mouse lens. FEBS J. 2012 Aug;279(16):2892-904
• All: 1 reference(s)