Robo2^tm1Mrt
Targeted Allele Detail

Summary

• Symbol: Robo2^tm1Mrt
• Name: roundabout guidance receptor 2; targeted mutation 1, Gail R Martin
• MGI ID: MGI:3043127
• Synonyms: Robo2-
• Gene: Robo2 Location: Chr16:73688727-74208713 bp, - strand Genetic Position: Chr16, 42.17 cM
• Alliance: Robo2^tm1Mrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90324
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' end of exon 1 including the ATG translational start site and part of the following intron were replaced with an IRES-tauLacZ cassette via homologous recombination. Northern and immunoblot analysis confirmed the absence of RNA and protein in homozygotes. (J:90324)

Expression

In Mice Carrying this Mutation:	88 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Robo2 Mutation: 101 strains or lines available

References

• Original: J:90324 Grieshammer U, et al., SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004 May;6(5):709-17
• All: 54 reference(s)