Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2tm1Mrt mutation
(2 available);
any
Robo2 mutation
(101 available)
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nervous system
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• thinner and spread along the ventrolateral surface of the telencephalon at E18
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2tm1Mrt mutation
(2 available);
any
Robo2 mutation
(101 available)
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mortality/aging
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• almost all homozygotes fail to survive after birth
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renal/urinary system
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• multiple ureters arising from a single kidney are seen with 6/14 kidneys having 3 ureters, 6/14 having 2 ureters, and 2 having only 1 ureter
• most of the ureters remain connected to the nephric duct rather than undergoing remodeling to connect to the bladder
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2tm1Mrt mutation
(2 available);
any
Robo2 mutation
(101 available)
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nervous system
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• appears to be ventrally displaced and corticofugal axons abnormally defasciculate in some mice at E18.5
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• at E18.5, a few corticofugal axons are ventrally displaced reaching the ventral midline at the level of the anterior commissure and occasional bundles of cortical fibers are found in the dorsal thalamus
• at E18.5, some thalamocortical fibers fail to reach the telencephalon and instead grow toward the ventral diencephalon and invade the hypothalamu
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2tm1Mrt mutation
(2 available);
any
Robo2 mutation
(101 available)
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nervous system
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• commissural axons remain tightly apposed to the floor plate rather than moving into more dorsal longitudinal tracts
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• the lateral funiculus (white matter tract) is foreshortened in homozygous mutants compared to wild-type mice as a result of abnormal commissural axon growth
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cellular
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• commissural axons remain tightly apposed to the floor plate rather than moving into more dorsal longitudinal tracts
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mortality/aging
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• die within minutes of birth
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homeostasis/metabolism
respiratory system
nervous system
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• olfactory bulb axons from E14 explants are not repelled by SLIT proteins
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• highly defasciculated into small axonal bundles fanned all over the ventral side of the telencephalon, at E15.5 and E18
• a subset of axons originating from the lateral bulb are still present in the normal location
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• at E11.5, commissural axons exhibit robust postcrossing trajectory defects with failure to project to the lateral portion of the funiculus and altered lateral and ventral funiculi ration compared with wild-type mice
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cellular
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• olfactory bulb axons from E14 explants are not repelled by SLIT proteins
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• in culture, fewer E10.5 foregut cells migrate away from SLIT2 containing media
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digestive/alimentary system
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• mispositioning of the stomach in the thoracic instead of the abdominal cavity
• abnormal midline position detected as early as E11.5
• more prominent at E13.5 and disrupts the diaphragm
• located at the midline and protrudes through the esophageal hiatus into the thoracic cavity in neonates
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• delayed separation of the foregut from the body wall
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muscle
behavior/neurological
cardiovascular system
cellular
nervous system
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• two large ectopic fiber bundles formed of corticocortical axons are seen on either side of the corpus callosum at E18.5
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• displaced dorsally due to the presence of ectopic fiber bundles
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• large bundles of ectopic fibers are seen crossing the ventral midline at the level of the anterior commissure and in the basal telencephalon at E18.5
• most corticofugal axons are diverted toward the midline
• only a few cortical axons reach the dorsal thalamus and those that do follow a more ventral trajectory
• virtually no corticospinal axons reach the diencephalon
• many thalamic axons abnormally invade the hypothalamus
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nervous system
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• at E11.5 embryos show no midline crossing and look identical to Robo3tm1Matl homozygous littermates
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cellular
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• at E11.5 embryos show no midline crossing and look identical to Robo3tm1Matl homozygous littermates
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Analysis Tools
