Kitl^Sl-5R
Spontaneous Allele Detail

Summary

• Symbol: Kitl^Sl-5R
• Name: kit ligand; steel 5 Oak Ridge
• MGI ID: MGI:2652949
• Gene: Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
• Alliance: Kitl^Sl-5R page

Mutation origin

• Strain of Origin: T stock x (101/Rl x C3H/Rl)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: Sequence analysis revealed an in-frame deletion of 6 nucleotides (AACTAT) at coding nucleotides 166-171 (transcript NM_013598) resulting in loss of asparagine 31 and tyrosine 32 (p.N31_Y32del on mature protein or p.N56_Y57del on pre-protein). These residues are located in the extracellular domain and are part of the beta strand structure between the first 2 alpha helical domains. (J:82263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kitl Mutation: 92 strains or lines available

References

• Original: J:82263 Rajaraman S, et al., Effects of spontaneous Kitl(Steel) mutations on survival and red blood cells of mice. Mamm Genome. 2003 Mar;14(3):168-74
• All: 2 reference(s)