Phenotypes associated with this allele

• Allele Symbol: Kitl^Sl-5R
• Allele Name: steel 5 Oak Ridge
• Allele ID: MGI:2652949
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kitl^Sl-5R/Kitl^Sl-5R	C3.Cg-Kitl^Sl-5R	MGI:2652966
hm2	Kitl^Sl-5R/Kitl^Sl-5R	C3H-Kitl^Sl-5R	MGI:3794661
ht3	Kitl^Sl-5R/Kitl^+	C3.Cg-Kitl^Sl-5R	MGI:2652977

Genotype
MGI:2652966

hm1

• Allelic Composition: Kitl^Sl-5R/Kitl^Sl-5R
• Genetic Background: C3.Cg-Kitl^Sl-5R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:82263 )

• only 70% of the expected numbers of homozygotes are observed at P1

postnatal lethality, complete penetrance ( J:82263 )

• almost 25% of homozygotes live past P2, unlike age-matched Kitl^Sl-gb homozygotes

• however, no homozygotes survive beyond P6

hematopoietic system

low mean erythrocyte cell number ( J:82263 )

• at P1, mean peripheral RBC counts are reduced to only 17% of wild-type controls, similar to mean RBC counts seen in age-matched Kitl^Sl-gb homozygotes

Genotype
MGI:3794661

hm2

• Allelic Composition: Kitl^Sl-5R/Kitl^Sl-5R
• Genetic Background: C3H-Kitl^Sl-5R

reproductive system

decreased primordial germ cell number ( J:115437 )

• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

cellular

decreased primordial germ cell number ( J:115437 )

• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

Genotype
MGI:2652977

ht3

• Allelic Composition: Kitl^Sl-5R/Kitl⁺
• Genetic Background: C3.Cg-Kitl^Sl-5R

hematopoietic system

decreased erythrocyte cell number ( J:82263 )

• at P1, mean peripheral RBC counts are 80% of wild-type values, suggesting a slightly milder anemia than that seen in age-matched Kitl^Sl-gb heterozygotes (71% of wild-type values)