Mrc1^tm1Mnz
Targeted Allele Detail

Summary

• Symbol: Mrc1^tm1Mnz
• Name: mannose receptor, C type 1; targeted mutation 1, Michel C Nussenzweig
• MGI ID: MGI:2448258
• Synonyms: CD206^-, MMR^-, MR^-
• Gene: Mrc1 Location: Chr2:14234225-14336834 bp, + strand Genetic Position: Chr2, 10.46 cM
• Alliance: Mrc1^tm1Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75364
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by an enhanced green fluorescent protein (eGFP) gene inserted at the endogenous start codon. A single loxP site remained downstream of eGFP after the removal of a floxed neo cassette. Western blot analysis of lymph node lysates indicated an absence of normal protein in homozygous mutant mice. (J:75364)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mrc1 Mutation: 85 strains or lines available

References

• Original: J:75364 Lee SJ, et al., Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science. 2002 Mar 8;295(5561):1898-901
• All: 43 reference(s)