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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mrc1tm1Mnz
targeted mutation 1, Michel C Nussenzweig
MGI:2448258
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mrc1tm1Mnz/Mrc1tm1Mnz B6.129P2-Mrc1tm1Mnz MGI:5486681
hm2
 		Mrc1tm1Mnz/Mrc1tm1Mnz involves: 129P2/OlaHsd MGI:3723178
cx3
 		Mrc1tm1Mnz/Mrc1tm1Mnz
Mrc2tm1Cmi/Mrc2tm1Cmi 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3723179


Genotype
MGI:5486681
hm1
Allelic
Composition		 Mrc1tm1Mnz/Mrc1tm1Mnz
Genetic
Background		 B6.129P2-Mrc1tm1Mnz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrc1tm1Mnz mutation (1 available); any Mrc1 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased granulocyte number ( J:194065 )
• mice show a decrease in the numbers of dendritic cells and monocytes/macrophages and an increased accumulation of granulocytic myeloid cells after Mesocestoides corti infection compared with wild-type mice
• granulocytes from Mesocestoides corti infected mutants exhibit a regulatory phenotype
decreased T cell number ( J:194065 )
• Mesocestoides corti infected mutants show diminished numbers of T cells in the brains compared to infected wild-type controls
decreased susceptibility to parasitic infection ( J:194065 )
• mutants show decreased susceptibility to infection with the parasite Mesocestoides corti, showing increased survival times after infection and decreased disease severity
• mutants exhibit lower levels of IL-1beta, CCL5 and IL-6 cytokines following Mesocestoides corti infection
• the immune cell subsets that infilatrate the brain following Mesocestoides croti infection are altered and characterized by reduced numbers of T cells and accumulation of granulocytic cells
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:194065 )
• mutants show increased survival times after infection with the parasite Mesocestoides corti compared to wild-type mice

mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:194065 )
• mutants show increased survival times after infection with the parasite Mesocestoides corti compared to wild-type mice

hematopoietic system
increased granulocyte number ( J:194065 )
• mice show a decrease in the numbers of dendritic cells and monocytes/macrophages and an increased accumulation of granulocytic myeloid cells after Mesocestoides corti infection compared with wild-type mice
• granulocytes from Mesocestoides corti infected mutants exhibit a regulatory phenotype
decreased T cell number ( J:194065 )
• Mesocestoides corti infected mutants show diminished numbers of T cells in the brains compared to infected wild-type controls




Genotype
MGI:3723178
hm2
Allelic
Composition		 Mrc1tm1Mnz/Mrc1tm1Mnz
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrc1tm1Mnz mutation (1 available); any Mrc1 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:124290 )
• migration distance and speed of bone marrow macrophages is increased compared to that of wild-type cells
• migration speed of bone marrow macrophages in response to colony stimulating factor-1 (CSF-1) is increased relative to that of wild-type cells
• however, membrane ruffling stimulated by CSF-1 is normal

hematopoietic system
abnormal macrophage physiology ( J:124290 )
• migration distance and speed of bone marrow macrophages is increased compared to that of wild-type cells
• migration speed of bone marrow macrophages in response to colony stimulating factor-1 (CSF-1) is increased relative to that of wild-type cells
• however, membrane ruffling stimulated by CSF-1 is normal




Genotype
MGI:3723179
cx3
Allelic
Composition		 Mrc1tm1Mnz/Mrc1tm1Mnz
Mrc2tm1Cmi/Mrc2tm1Cmi
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrc1tm1Mnz mutation (1 available); any Mrc1 mutation (85 available)
Mrc2tm1Cmi mutation (4 available); any Mrc2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:124290 )
• bone marrow macrophages are defective in binding and internalizing OG-gelatin
• bone marrow macrophages have increased migration speed relative to control cells

hematopoietic system
abnormal macrophage physiology ( J:124290 )
• bone marrow macrophages are defective in binding and internalizing OG-gelatin
• bone marrow macrophages have increased migration speed relative to control cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory