Del(2Hoxd11-Hoxd13)2Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd11-Hoxd13)2Ddu
• Name: deletion, Chr 2, Denis Duboule 1; deletion, Chr 2, Denis Duboule 2
• MGI ID: MGI:2445981
• Synonyms: Del2Ddu, HoxD^del(d13-11), Hoxd^tm10Ddu
• Gene: Del(2Hoxd11-Hoxd13)2Ddu Location: Chr2:74498654-74517360 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80084
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd11-Hoxd13)2Ddu involves 4 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: Hoxd11, Hoxd12, Hoxd13, and regions VIII through XI were deleted via trans-allelic meiotic recombination (TAMERE). The deletion was accomplished by recombination of a single loxP site in the intergenic region between Evx2 and Hoxd13 (Evx2/Hoxd13^tm1.1Ddu) and a single loxP on the opposite chromosome downstream of region XI (Hoxd^tm5Ddu). (J:80084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd11-Hoxd13)2Ddu Mutation: 1 strain or line available

References

• Original: J:80084 Kmita M, et al., Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells. Development. 2002 Dec;129(23):5521-8
• All: 3 reference(s)