Ucp3^tm1Brnd
Targeted Allele Detail

Summary

• Symbol: Ucp3^tm1Brnd
• Name: uncoupling protein 3 (mitochondrial, proton carrier); targeted mutation 1, Martin D Brand
• MGI ID: MGI:2183204
• Gene: Ucp3 Location: Chr7:100122198-100135639 bp, + strand Genetic Position: Chr7, 54.36 cM
• Alliance: Ucp3^tm1Brnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 2.5 kb of sequence, including exons 1 and 2, was deleted and replaced by a neomycin selection cassette. The absence of transcript and protein was confirmed via Northern blot analysis of skeletal muscle RNA and Western blot analysis of mitochondria, respectively. (J:78047)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucp3 Mutation: 4 strains or lines available

References

• Original: J:78047 Echtay KS, et al., Superoxide activates mitochondrial uncoupling proteins. Nature. 2002 Jan 3;415(6867):96-9
• All: 5 reference(s)