Ptger2^tm1Rsz
Targeted Allele Detail

Summary

• Symbol: Ptger2^tm1Rsz
• Name: prostaglandin E receptor 2 (subtype EP2); targeted mutation 1, Lawrence G Raisz
• MGI ID: MGI:2181616
• Synonyms: EP2 -
• Gene: Ptger2 Location: Chr14:45225652-45241277 bp, + strand Genetic Position: Chr14, 22.68 cM
• Alliance: Ptger2^tm1Rsz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77408
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of the amino-terminal coding sequence was replaced with a PGK-neo cassette. RT-PCR analysis showed a lack of transcript in spleen cells obtained from homozygous mutant mice. (J:77408)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger2 Mutation: 31 strains or lines available

References

• Original: J:77408 Li X, et al., Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro. Endocrinology. 2000 Jun;141(6):2054-61
• All: 1 reference(s)