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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptger2tm1Rsz
targeted mutation 1, Lawrence G Raisz
MGI:2181616
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptger2tm1Rsz/Ptger2tm1Rsz involves: 129S6/SvEvTac * C57BL/6 MGI:3845254


Genotype
MGI:3845254
hm1
Allelic
Composition		 Ptger2tm1Rsz/Ptger2tm1Rsz
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Rsz mutation (0 available); any Ptger2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:77408 )
• cells in culture respond much less to PGE2, PTH, and 1,25 dihydroxyvitamin D to become tartrate resistant acid phosphatase positive multinucleate cells

hematopoietic system
abnormal osteoclast differentiation ( J:77408 )
• cells in culture respond much less to PGE2, PTH, and 1,25 dihydroxyvitamin D to become tartrate resistant acid phosphatase positive multinucleate cells

immune system
abnormal osteoclast differentiation ( J:77408 )
• cells in culture respond much less to PGE2, PTH, and 1,25 dihydroxyvitamin D to become tartrate resistant acid phosphatase positive multinucleate cells

cellular
abnormal osteoclast differentiation ( J:77408 )
• cells in culture respond much less to PGE2, PTH, and 1,25 dihydroxyvitamin D to become tartrate resistant acid phosphatase positive multinucleate cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory