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Usf2 Gene Detail
Summary
  • Symbol
    Usf2
  • Name
    upstream transcription factor 2
  • Synonyms
    bHLHb12, Usf-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99961
    NCBI Gene: 22282
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30645421-30656288 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.27 cM, cytoband A2-B1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99961
 protein coding gene Chr7:30644673-30656288 (-)
129S1/SvImJ ENSMUSG00200022765
 protein coding gene Chr7:20413686-20425242 (-)
A/J ENSMUSG00195039590
 protein coding gene Chr7:23089700-23101261 (-)
AKR/J ENSMUSG00220046620
 protein coding gene Chr7:21376677-21388237 (+)
BALB/cJ ENSMUSG00180014725
 protein coding gene Chr7:21149184-21160751 (-)
C3H/HeJ ENSMUSG00175034297
 protein coding gene Chr7:22233773-22245329 (-)
C57BL/6NJ ENSMUSG00215008005
 protein coding gene Chr7:20335972-20347529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029553
 protein coding gene Chr7:30146564-30158230 (-)
CAST/EiJ ENSTCUG00005040203
 protein coding gene Chr7:22121478-22133028 (-)
CBA/J ENSMUSG00210025015
 protein coding gene Chr7:21396381-21407936 (-)
DBA/2J ENSMUSG00185050684
 protein coding gene Chr7:24471566-24483133 (-)
FVB/NJ ENSMUSG00205009954
 protein coding gene Chr7:21145852-21157411 (-)
JF1/MsJ ENSUMUG00000028555
 protein coding gene Chr7:28912999-28924566 (-)
LP/J ENSMUSG00230053505
 protein coding gene Chr7:29646818-29658376 (-)
NOD/ShiLtJ ENSMUSG00190007651
 protein coding gene Chr7:20814021-20825580 (-)
NZO/HlLtJ ENSMUSG00225023952
 protein coding gene Chr7:28467866-28490531 (-)
PWK/PhJ ENSLUMG00010017967
 protein coding gene Chr7:20840510-20852078 (-)
SPRET/EiJ ENSMSPG00010034041
 protein coding gene Chr7:20200412-20224800 (-)
WSB/EiJ ENSIUOG00005049929
 protein coding gene Chr7:15091431-15102990 (-)



Homology
more
  • Human Ortholog
    USF2, upstream transcription factor 2, c-fos interacting
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USF2, upstream transcription factor 2, c-fos interacting
  • Synonyms
    bHLHb12, FIP
  • Links
    NCBI Gene ID: 7392
    UniProt: Q15853

  • Chr Location
    19q13.12; chr19:35268962-35279821 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are 20-40% smaller at birth and > 50% die postnatally, possibly because they are unable to nurse. In survivors, a proportionate dwarfism is maintained into adulthood. Males are usually infertile and die before 6 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    689
  • Tissues
    81
  • cDNA Data
    84
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22282 NCBI Gene Model | MGI Sequence Detail 10868 C57BL/6J ±  kb
    transcript NM_011680 RefSeq | MGI Sequence Detail 1731 ZRU/MplStud  
    polypeptide Q64705 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 10
      cDNA 86
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16766
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:17048 Sirito M, et al., Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 1994 Feb 11;22(3):427-33
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory