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Cmpk2 Gene Detail
Summary
  • Symbol
    Cmpk2
  • Name
    cytidine/uridine monophosphate kinase 2
  • Synonyms
    1200004E04Rik, TDKI, Tyki
  • Feature Type
    protein coding gene
  • IDs
    MGI:99830
    NCBI Gene: 22169
  • Alliance
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:26519203-26529836 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 9.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    380 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99830
protein coding gene Chr12:26519121-26529836 (+)
129S1/SvImJ ENSMUSG00200022490
protein coding gene Chr12:18256013-18266679 (+)
A/J ENSMUSG00195021902
protein coding gene Chr12:20990150-21000822 (+)
AKR/J ENSMUSG00220026964
protein coding gene Chr12:18936037-18946650 (+)
BALB/cJ ENSMUSG00180009086
protein coding gene Chr12:19932861-19943534 (+)
C3H/HeJ ENSMUSG00175020674
protein coding gene Chr12:22981075-22991738 (+)
C57BL/6NJ ENSMUSG00215005114
protein coding gene Chr12:19415827-19426459 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017654
protein coding gene Chr12:23004196-23014809 (+)
CAST/EiJ ENSTCUG00005005451
protein coding gene Chr12:19803664-19814341 (+)
CBA/J ENSMUSG00210007396
protein coding gene Chr12:19467270-19477933 (+)
DBA/2J ENSMUSG00185015179
protein coding gene Chr12:21490556-21501169 (+)
FVB/NJ ENSMUSG00205001378
protein coding gene Chr12:19561533-19572198 (+)
JF1/MsJ ENSUMUG00000005789
protein coding gene Chr12:25733518-25744151 (+)
LP/J ENSMUSG00230006875
protein coding gene Chr12:28459830-28471120 (+)
NOD/ShiLtJ ENSMUSG00190013257
protein coding gene Chr12:18439627-18450298 (+)
NZO/HlLtJ ENSMUSG00225033678
protein coding gene Chr12:30652657-30663945 (+)
PWK/PhJ ENSLUMG00010003957
protein coding gene Chr12:19990644-20001299 (+)
SPRET/EiJ ENSMSPG00010005512
protein coding gene Chr12:20266158-20277396 (+)
WSB/EiJ ENSIUOG00005001521
protein coding gene Chr12:19134339-19144948 (+)



Homology
more
  • Human Ortholog
    CMPK2, cytidine/uridine monophosphate kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CMPK2, cytidine/uridine monophosphate kinase 2
  • Synonyms
    IBGC10, NDK, TMPK2, TYKi, UMP-CMPK2
  • Links
    NCBI Gene ID: 129607
    UniProt: Q5EBM0

  • Chr Location
    2p25.2; chr2:6840553-6866635 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for knockout or loss of the start codon affects mitochondrial morphology and physiology and leads to brain calcification.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020638 Ensembl Gene Model | MGI Sequence Detail 10634 C57BL/6J ±  kb
    transcript ENSMUST00000020969 Ensembl | MGI Sequence Detail 3200 Not Applicable  
    polypeptide ENSMUSP00000020969 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16617, MGI:1918964
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:21542 Lee CG, et al., Localization of a novel, LPS-inducible member of the thymidylate kinase family to mouse chromosome 12. Mamm Genome. 1994 Nov;5(11):742-3
    • Latest
      J:359885 Natarajan N, et al., Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis. Nat Commun. 2024 Aug 26;15(1):7337

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/15/2026
    MGI 6.29
    The Jackson Laboratory