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Sct Gene Detail
Summary
  • Symbol
    Sct
  • Name
    secretin
  • Feature Type
    protein coding gene
  • IDs
    MGI:99466
    NCBI Gene: 20287
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140858243-140859046 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.59 cM, cytoband F5
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99466
 protein coding gene Chr7:140858243-140859082 (-)
129S1/SvImJ ENSMUSG00200043722
 protein coding gene Chr7:127423622-127424767 (-)
A/J ENSMUSG00195040127
 protein coding gene Chr7:131906101-131907246 (-)
AKR/J ENSMUSG00220028916
 protein coding gene Chr7:125387783-125388928 (-)
BALB/cJ ENSMUSG00180036941
 protein coding gene Chr7:128598254-128599399 (-)
C3H/HeJ ENSMUSG00175037414
 protein coding gene Chr7:129326533-129327678 (-)
C57BL/6NJ ENSMUSG00215047128
 protein coding gene Chr7:128593105-128594250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030688
 protein coding gene Chr7:143481062-143481883 (-)
CAST/EiJ ENSTCUG00005047688
 protein coding gene Chr7:131898987-131900132 (-)
CBA/J ENSMUSG00210028894
 protein coding gene Chr7:129084544-129085689 (-)
DBA/2J ENSMUSG00185016471
 protein coding gene Chr7:133363087-133364232 (-)
FVB/NJ ENSMUSG00205032689
 protein coding gene Chr7:129005357-129006502 (-)
JF1/MsJ ENSUMUG00000026481
 protein coding gene Chr7:138441454-138442599 (-)
LP/J ENSMUSG00230041837
 protein coding gene Chr7:139526555-139527700 (-)
NOD/ShiLtJ ENSMUSG00190021587
 protein coding gene Chr7:129191986-129193131 (-)
NZO/HlLtJ ENSMUSG00225049915
 protein coding gene Chr7:137735759-137736904 (-)
PWK/PhJ ENSLUMG00010035141
 protein coding gene Chr7:127572522-127573667 (-)
SPRET/EiJ ENSMSPG00010037819
 protein coding gene Chr7:129016742-129017544 (-)
WSB/EiJ ENSIUOG00005030645
 protein coding gene Chr7:129925327-129926472 (-)



Homology
more
  • Human Ortholog
    SCT, secretin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCT, secretin
  • Links
    NCBI Gene ID: 6343
    UniProt: P09683

  • Chr Location
    11p15.5; chr11:626309-627181 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired hippocampal synaptic function. Mice homozygous for a different knock-out allele fail to exhibit increased water consumption or vasopressin serum levels in response to ANGII treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    676
  • Tissues
    43
  • cDNA Data
    22
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038580 Ensembl Gene Model | MGI Sequence Detail 804 C57BL/6J ±  kb
    transcript ENSMUST00000046156 Ensembl | MGI Sequence Detail 534 Not Applicable  
    polypeptide ENSMUSP00000041519 Ensembl | MGI Sequence Detail 139 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 22
      Primer pair 1
      Other 1
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16237
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 27
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:17989 Lan MS, et al., cDNA sequence and genomic organization of mouse secretin. Biochem Biophys Res Commun. 1994 Apr 29;200(2):1066-71
    • Latest
      J:374474 Jimenez S, et al., Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development. Biol Open. 2025 Oct 15;14(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory