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Vil1 Gene Detail
Summary
  • Symbol
    Vil1
  • Name
    villin 1
  • Synonyms
    Villin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98930
    NCBI Gene: 22349
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74448543-74474719 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C5
  • Mapping Data
    56 experiments
Strain
Comparison
more
  • SNPs within 2kb
    808 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98930
 protein coding gene Chr1:74448535-74474719 (+)
129S1/SvImJ ENSMUSG00200031978
 protein coding gene Chr1:72111466-72137881 (+)
A/J ENSMUSG00195008249
 protein coding gene Chr1:71536394-71562763 (+)
AKR/J ENSMUSG00220010271
 protein coding gene Chr1:71682144-71708578 (+)
BALB/cJ ENSMUSG00180016884
 protein coding gene Chr1:71795222-71821400 (+)
C3H/HeJ ENSMUSG00175015131
 protein coding gene Chr1:71936780-71963151 (+)
C57BL/6NJ ENSMUSG00215009982
 protein coding gene Chr1:71840540-71866721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014263
 protein coding gene Chr1:67968434-67994741 (+)
CAST/EiJ ENSTCUG00005027131
 protein coding gene Chr1:71564745-71590967 (+)
CBA/J ENSMUSG00210033131
 protein coding gene Chr1:71620921-71647338 (+)
DBA/2J ENSMUSG00185029666
 protein coding gene Chr1:72714780-72741207 (+)
FVB/NJ ENSMUSG00205032444
 protein coding gene Chr1:71290146-71316324 (+)
JF1/MsJ ENSUMUG00000004562
 protein coding gene Chr1:71615201-71641321 (+)
LP/J ENSMUSG00230009584
 protein coding gene Chr1:72704645-72731065 (+)
NOD/ShiLtJ ENSMUSG00190032760
 protein coding gene Chr1:71846749-71873179 (+)
NZO/HlLtJ ENSMUSG00225038590
 protein coding gene Chr1:75919751-75946168 (+)
PWK/PhJ ENSLUMG00010012980
 protein coding gene Chr1:71191261-71217409 (+)
SPRET/EiJ ENSMSPG00010017687
 protein coding gene Chr1:73292425-73318633 (+)
WSB/EiJ ENSIUOG00005012205
 protein coding gene Chr1:71468491-71494899 (+)



Homology
more
  • Human Ortholog
    VIL1, villin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VIL1, villin 1
  • Synonyms
    D2S1471, VIL
  • Links
    NCBI Gene ID: 7429
    UniProt: P09327

  • Chr Location
    2q35; chr2:218419083-218453295 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants do not exhibit gross abnormalities or apparent defects of microvilli morphogenesis, however in one line, an increased sensitivity to colitis induced by dextran sulfate was observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    168
  • cDNA Data
    12
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22349 NCBI Gene Model | MGI Sequence Detail 26177 C57BL/6J ±  kb
    transcript NM_009509 RefSeq | MGI Sequence Detail 3117 ZRU/MplStud  
    polypeptide Q62468 UniProt | EBI | MGI Sequence Detail 827 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 16
      Primer pair 5
      Other 3
      Antibodies 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15393
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 52
      Gene Ontology 15
      Phenotypes 39
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:389438 Srinivasan T, et al., The gut microbiota directs vitamin A flux to regulate intestinal T cell development. Cell Host Microbe. 2026 Jun 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory