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Scgb1a1 Gene Detail
Summary
  • Symbol
    Scgb1a1
  • Name
    secretoglobin, family 1A, member 1
  • Synonyms
    Blastokinin, CC10, CC16, CCSP, club cell secretory protein, PCB-BP, UG, Utg
  • Feature Type
    protein coding gene
  • IDs
    MGI:98919
    NCBI Gene: 22287
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:9061006-9065320 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.05 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98919
 protein coding gene Chr19:9061000-9065322 (-)
129S1/SvImJ ENSMUSG00200052164
 protein coding gene Chr19:5786743-5791067 (-)
A/J ENSMUSG00195045422
 protein coding gene Chr19:6188585-6192919 (-)
AKR/J ENSMUSG00220049956
 protein coding gene Chr19:5961304-5965625 (-)
BALB/cJ ENSMUSG00180050329
 protein coding gene Chr19:6552555-6556887 (-)
C3H/HeJ ENSMUSG00175013576
 protein coding gene Chr19:5826294-5830628 (-)
C57BL/6NJ ENSMUSG00215045647
 protein coding gene Chr19:6027237-6031561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022673
 protein coding gene Chr19:6291904-6296219 (-)
CAST/EiJ ENSTCUG00005034626
 protein coding gene Chr19:5663725-5668287 (-)
CBA/J ENSMUSG00210044344
 protein coding gene Chr19:5841737-5846061 (-)
DBA/2J ENSMUSG00185051900
 protein coding gene Chr19:6196394-6200720 (-)
FVB/NJ ENSMUSG00205049998
 protein coding gene Chr19:5884153-5888475 (-)
JF1/MsJ ENSUMUG00000013487
 protein coding gene Chr19:6434370-6438643 (-)
LP/J ENSMUSG00230052460
 protein coding gene Chr19:7113372-7117695 (-)
NOD/ShiLtJ ENSMUSG00190026743
 protein coding gene Chr19:5721793-5726119 (-)
NZO/HlLtJ ENSMUSG00225046064
 protein coding gene Chr19:10822188-10826510 (-)
PWK/PhJ ENSLUMG00010006043
 protein coding gene Chr19:5870340-5874848 (-)
SPRET/EiJ ENSMSPG00010043706
 protein coding gene Chr19:5773865-5778034 (-)
WSB/EiJ ENSIUOG00005045354
 protein coding gene Chr19:5550327-5554656 (-)



Homology
more
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
  • Synonyms
    CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1
  • Links
    NCBI Gene ID: 7356
    UniProt: P11684

  • Chr Location
    11q12.3; chr11:62405103-62423195 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scgb1a1 mouse models; 3 with human SCGB1A1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 6 genetic backgrounds
    22 phenotypes from multigenic genotypes
    184 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit progressive renal glomerular disease characterized by proteinuria and hypocalcemia, necrotic pancreatic foci, reduced pulmonary neuroendocrine bodies, weight loss, cachexia, and premature mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    70
  • cDNA Data
    271
  • Literature Summary
    296
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22287 NCBI Gene Model | MGI Sequence Detail 4315 C57BL/6J ±  kb
    transcript NM_011681 RefSeq | MGI Sequence Detail 468 C57BL/6  
    polypeptide Q06318 UniProt | EBI | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 303
      Genomic 4
      cDNA 274
      Primer pair 16
      Other 9
      Antibodies 40

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15376
    References
    more
    • Summaries
      All 584
      Developmental Gene Expression 296
      Diseases 2
      Gene Ontology 8
      Phenotypes 184
    • Earliest
      J:34757 Hagen G, et al., Tissue-specific expression, hormonal regulation and 5'-flanking gene region of the rat Clara cell 10 kDa protein: comparison to rabbit uteroglobin. Nucleic Acids Res. 1990 May 25;18(10):2939-46
    • Latest
      J:391820 Skibba M, et al., RelA Signaling in Scgb1a1+ Progenitors Mediates Lower Airway Epithelial Atypia in RSV-Induced Post-Viral Lung Disease. Int J Mol Sci. 2026 Mar 21;27(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory