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Ift88 Gene Detail
Summary
  • Symbol
    Ift88
  • Name
    intraflagellar transport 88
  • Synonyms
    fxo, IFT88, Oak Ridge polycystic kidneys, orpk, polaris, Tg737, Tg737Rpw, TgN737Rpw, Ttc10
  • Feature Type
    protein coding gene
  • IDs
    MGI:98715
    NCBI Gene: 21821
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:57661519-57755393 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2042 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98715
 protein coding gene Chr14:57661519-57755393 (+)
129S1/SvImJ ENSMUSG00200039132
 protein coding gene Chr14:46253235-46340643 (+)
A/J ENSMUSG00195027691
 protein coding gene Chr14:46468501-46555898 (+)
AKR/J ENSMUSG00220024002
 protein coding gene Chr14:45795450-45882862 (+)
BALB/cJ ENSMUSG00180051568
 protein coding gene Chr14:46090523-46177923 (+)
C3H/HeJ ENSMUSG00175047587
 protein coding gene Chr14:47797055-47884460 (+)
C57BL/6NJ ENSMUSG00215045949
 protein coding gene Chr14:45991188-46078595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019349
 protein coding gene Chr14:48673039-48763857 (+)
CAST/EiJ ENSTCUG00005045573
 protein coding gene Chr14:47773438-47856332 (+)
CBA/J ENSMUSG00210043054
 protein coding gene Chr14:46458866-46546279 (+)
DBA/2J ENSMUSG00185031294
 protein coding gene Chr14:51591878-51679092 (+)
FVB/NJ ENSMUSG00205038440
 protein coding gene Chr14:45860873-45948282 (+)
JF1/MsJ ENSUMUG00000025274
 protein coding gene Chr14:62766234-62849368 (+)
LP/J ENSMUSG00230034645
 protein coding gene Chr14:63622245-63709640 (+)
NOD/ShiLtJ ENSMUSG00190038225
 protein coding gene Chr14:46225203-46312605 (+)
NZO/HlLtJ ENSMUSG00225045005
 protein coding gene Chr14:53915550-54002948 (+)
PWK/PhJ ENSLUMG00010039051
 protein coding gene Chr14:45684790-45772235 (+)
SPRET/EiJ ENSMSPG00010039126
 protein coding gene Chr14:49200461-49290376 (+)
WSB/EiJ ENSIUOG00005040362
 protein coding gene Chr14:45652851-45740083 (+)



Homology
more
  • Human Ortholog
    IFT88, intraflagellar transport 88
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT88, intraflagellar transport 88
  • Synonyms
    D13S1056E, DAF19, hTg737, TG737, TTC10
  • Links
    NCBI Gene ID: 8100
    UniProt: Q13099

  • Chr Location
    13q12.11; chr13:20566600-20691697 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ift88 mouse models

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    111 phenotypes from 7 alleles in 19 genetic backgrounds
    15 phenotypes from multigenic genotypes
    219 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display early to mid-gestation lethality, random patterning of the left-right body axis, neural tube defects, pericardial sac expansion, enlarged limb buds, polydactyly, and absent embryonic node cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    135
  • GO References
    71
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    75
  • cDNA Data
    36
  • Literature Summary
    77
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21821 NCBI Gene Model | MGI Sequence Detail 93875 C57BL/6J ±  kb
    transcript NM_001404396 RefSeq | MGI Sequence Detail 3124 ZRU/MplStud  
    polypeptide Q61371 UniProt | EBI | MGI Sequence Detail 824 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 6
      cDNA 38
      Primer pair 8
      Antibodies 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15052, MGI:2145834
    References
    more
    • Summaries
      All 356
      Developmental Gene Expression 77
      Diseases 8
      Gene Ontology 71
      Phenotypes 219
    • Earliest
      J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
    • Latest
      J:391278 Kim JM, et al., Exercise-stimulated primary cilia on preosteoclasts promote periosteal-bone formation. Exp Mol Med. 2026 Jul;58(7):2168-2183
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory