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Ssb Gene Detail
Summary
  • Symbol
    Ssb
  • Name
    small RNA binding exonuclease protection factor La
  • Synonyms
    autoantigen La, La protein, Sjogren syndrome antigen B, SS-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:98423
    NCBI Gene: 20823
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69691963-69702185 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 40.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98423
 protein coding gene Chr2:69691906-69702190 (+)
129S1/SvImJ ENSMUSG00200036248
 protein coding gene Chr2:66752944-66761566 (+)
A/J ENSMUSG00195020659
 protein coding gene Chr2:66904261-66912886 (+)
AKR/J ENSMUSG00220035725
 protein coding gene Chr2:66869112-66877737 (+)
BALB/cJ ENSMUSG00180036695
 protein coding gene Chr2:66849191-66857815 (+)
C3H/HeJ ENSMUSG00175035107
 protein coding gene Chr2:66968498-66977122 (+)
C57BL/6NJ ENSMUSG00215024232
 protein coding gene Chr2:66789345-66797967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023629
 protein coding gene Chr2:64390722-64400918 (+)
CAST/EiJ ENSTCUG00005009156
 protein coding gene Chr2:66268426-66277051 (+)
CBA/J ENSMUSG00210033918
 protein coding gene Chr2:67008786-67017410 (+)
DBA/2J ENSMUSG00185037272
 protein coding gene Chr2:66844346-66852970 (+)
FVB/NJ ENSMUSG00205032843
 protein coding gene Chr2:66318042-66326667 (+)
JF1/MsJ ENSUMUG00000003685
 protein coding gene Chr2:66514129-66522739 (+)
LP/J ENSMUSG00230018977
 protein coding gene Chr2:68649818-68658442 (+)
NOD/ShiLtJ ENSMUSG00190031187
 protein coding gene Chr2:66937638-66946263 (+)
NZO/HlLtJ ENSMUSG00225014293
 protein coding gene Chr2:76392071-76400695 (+)
PWK/PhJ ENSLUMG00010028502
 protein coding gene Chr2:66733035-66741644 (+)
SPRET/EiJ ENSMSPG00010032054
 protein coding gene Chr2:68136944-68147208 (+)
WSB/EiJ ENSIUOG00005019291
 protein coding gene Chr2:66982934-66991553 (+)



Homology
more
  • Human Ortholog
    SSB, small RNA binding exonuclease protection factor La
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSB, small RNA binding exonuclease protection factor La
  • Synonyms
    La, LARP3, La/SSB, SSB/La
  • Links
    NCBI Gene ID: 6741
    UniProt: P05455

  • Chr Location
    2q31.1; chr2:169791933-169812091 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos, possible before implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    648
  • Tissues
    41
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20823 NCBI Gene Model | MGI Sequence Detail 10223 C57BL/6J ±  kb
    transcript NM_001421045 RefSeq | MGI Sequence Detail 2952 ZRU/MplStud  
    polypeptide P32067 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14607
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:4633 Topfer F, et al., Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies. J Immunol. 1993 Apr 1;150(7):3091-100
    • Latest
      J:321251 Yang N, et al., Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. J Dent Res. 2022 Feb;101(2):226-234
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory