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Spn Gene Detail
Summary
  • Symbol
    Spn
  • Name
    sialophorin
  • Synonyms
    3E8 antigen, A630014B01Rik, Cd43, Galgp, leukosialin, Ly-48, Ly48
  • Feature Type
    protein coding gene
  • IDs
    MGI:98384
    NCBI Gene: 20737
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126731404-126736995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.35 cM, cytoband F3-F4
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98384
 protein coding gene Chr7:126731404-126743785 (-)
129S1/SvImJ ENSMUSG00200021435
 protein coding gene Chr7:113243082-113248673 (-)
A/J ENSMUSG00195036855
 protein coding gene Chr7:117759241-117764832 (-)
AKR/J ENSMUSG00220021824
 protein coding gene Chr7:111191944-111197536 (-)
BALB/cJ ENSMUSG00180013080
 protein coding gene Chr7:114432775-114438366 (-)
C3H/HeJ ENSMUSG00175016442
 protein coding gene Chr7:115159787-115165378 (-)
C57BL/6NJ ENSMUSG00215027316
 protein coding gene Chr7:114439760-114445351 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030488
 protein coding gene Chr7:129171943-129174899 (-)
CAST/EiJ ENSTCUG00005045670
 protein coding gene Chr7:117657762-117663375 (-)
CBA/J ENSMUSG00210022856
 protein coding gene Chr7:114920854-114926445 (-)
DBA/2J ENSMUSG00185037852
 protein coding gene Chr7:119233698-119239289 (-)
FVB/NJ ENSMUSG00205019000
 protein coding gene Chr7:114876617-114882208 (-)
JF1/MsJ ENSUMUG00000032405
 protein coding gene Chr7:124293316-124298933 (-)
LP/J ENSMUSG00230052941
 protein coding gene Chr7:125343053-125348644 (-)
NOD/ShiLtJ ENSMUSG00190015722
 protein coding gene Chr7:115080330-115085921 (-)
NZO/HlLtJ ENSMUSG00225012162
 protein coding gene Chr7:123573024-123578615 (-)
PWK/PhJ ENSLUMG00010033390
 protein coding gene Chr7:113430833-113436453 (-)
SPRET/EiJ ENSMSPG00010012158
 protein coding gene Chr7:114696568-114698325 (-)
WSB/EiJ ENSIUOG00005025096
 protein coding gene Chr7:115782102-115787678 (-)



Homology
more
  • Human Ortholog
    SPN, sialophorin
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPN, sialophorin
  • Synonyms
    CD43, GALGP, GPL115, LEU-22, LSN
  • Links
    NCBI Gene ID: 6693
    UniProt: P16150

  • Chr Location
    16p11.2; chr16:29662963-29670876 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show increased T cell proliferation in response to various stimulation agents and natural antigens, enhanced homotypic adhesion, transient resistance to melanoma growth and metastasis, and decreased susceptibility to experimental autoimmune encephalomyelitis. Adult mice heterozygous for a different knock-out allele show increased corpus callosum size in both sexes, and a female-specific increase in the area of the of the internal capsule and hippocampal fimbria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    13
  • cDNA Data
    35
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051457 Ensembl Gene Model | MGI Sequence Detail 5592 C57BL/6J ±  kb
    transcript ENSMUST00000143713 Ensembl | MGI Sequence Detail 2161 Not Applicable  
    polypeptide ENSMUSP00000122787 Ensembl | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 5
      cDNA 36
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11990, MGD-MRK-14534, MGD-MRK-1861, MGI:2443309
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 35
      Phenotypes 104
    • Earliest
      J:10530 Cyster J, et al., Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol. 1990 Apr;20(4):875-81
    • Latest
      J:389705 Hao L, et al., Heart rate and sleep history encode ultradian REM sleep timing. Curr Biol. 2026 Mar 23;36(6):1422-1434.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory