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Ski Gene Detail
Summary
  • Symbol
    Ski
  • Name
    ski proto-oncogene
  • Synonyms
    2310012I02Rik, 2610001A11Rik, MGC:8300
  • Feature Type
    protein coding gene
  • IDs
    MGI:98310
    NCBI Gene: 20481
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155238532-155307049 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2198 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98310
 protein coding gene Chr4:155238532-155307536 (-)
129S1/SvImJ ENSMUSG00200018960
 protein coding gene Chr4:146293162-146361983 (-)
A/J ENSMUSG00195019252
 protein coding gene Chr4:147959154-148028003 (-)
AKR/J ENSMUSG00220025955
 protein coding gene Chr4:147534617-147603455 (-)
BALB/cJ ENSMUSG00180002484
 protein coding gene Chr4:145608350-145677051 (-)
C3H/HeJ ENSMUSG00175018023
 protein coding gene Chr4:148914458-148983288 (-)
C57BL/6NJ ENSMUSG00215023853
 protein coding gene Chr4:147760573-147829432 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026885
 protein coding gene Chr4:145060391-145128953 (-)
CAST/EiJ ENSTCUG00005032679
 protein coding gene Chr4:151620413-151689360 (-)
CBA/J ENSMUSG00210003645
 protein coding gene Chr4:147572786-147641617 (-)
DBA/2J ENSMUSG00185015045
 protein coding gene Chr4:151130374-151199205 (-)
FVB/NJ ENSMUSG00205011704
 protein coding gene Chr4:146026555-146095402 (-)
JF1/MsJ ENSUMUG00000000059
 protein coding gene Chr4:154161653-154230919 (-)
LP/J ENSMUSG00230025668
 protein coding gene Chr4:157856285-157924998 (-)
NOD/ShiLtJ ENSMUSG00190003582
 protein coding gene Chr4:147229857-147298920 (-)
NZO/HlLtJ ENSMUSG00225024268
 protein coding gene Chr4:161852839-161921757 (-)
PWK/PhJ ENSLUMG00010026273
 protein coding gene Chr4:146418321-146487391 (-)
SPRET/EiJ ENSMSPG00010018899
 protein coding gene Chr4:148357515-148425663 (-)
WSB/EiJ ENSIUOG00005005971
 protein coding gene Chr4:145441470-145510382 (-)



Homology
more
  • Human Ortholog
    SKI, SKI proto-oncogene
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKI, SKI proto-oncogene
  • Synonyms
    SGS, SKV
  • Links
    NCBI Gene ID: 6497
    UniProt: P12755

  • Chr Location
    1p36.33-p36.32; chr1:2227388-2310213 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die during late gestation and exhibit neural tube defects, craniofacial anomalies, and reduced skeletal muscle mass. Haploinsufficient mice have an increased susceptibility to tumorigenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    15
  • cDNA Data
    22
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029050 Ensembl Gene Model | MGI Sequence Detail 68518 C57BL/6J ±  kb
    transcript ENSMUST00000030917 Ensembl | MGI Sequence Detail 5522 Not Applicable  
    polypeptide ENSMUSP00000030917 Ensembl | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 4
      cDNA 24
      Primer pair 1
      Other 2
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14428, MGI:1915543, MGI:1916864, MGI:2136877, MGI:2140114, MGI:2140167
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 12
      Gene Ontology 24
      Phenotypes 25
    • Earliest
      J:9932 Nomura N, et al., Isolation of human cDNA clones of ski and the ski-related gene, sno. Nucleic Acids Res. 1989 Jul 25;17(14):5489-500
    • Latest
      J:363341 Chiu H, et al., SKI Regulates Medullary Thymic Epithelial Cell Differentiation to Control Peripheral T Cell Responses in Mice. J Immunol. 2024 Jul 1;213(1):52-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory