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Scg5 Gene Detail
Summary
  • Symbol
    Scg5
  • Name
    secretogranin V
  • Synonyms
    7B2, Sgne-1, Sgne1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98289
    NCBI Gene: 20394
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:113606708-113659423 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 57.45 cM, cytoband E5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1382 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98289
 protein coding gene Chr2:113606707-113659466 (-)
129S1/SvImJ ENSMUSG00200006668
 protein coding gene Chr2:110494599-110547349 (-)
A/J ENSMUSG00195028196
 protein coding gene Chr2:110565472-110611089 (-)
AKR/J ENSMUSG00220004806
 protein coding gene Chr2:110461030-110506630 (-)
BALB/cJ ENSMUSG00180031798
 protein coding gene Chr2:110360707-110406321 (-)
C3H/HeJ ENSMUSG00175028730
 protein coding gene Chr2:110799284-110847618 (-)
C57BL/6NJ ENSMUSG00215024590
 protein coding gene Chr2:110508535-110561302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024099
 protein coding gene Chr2:106691833-106738017 (-)
CAST/EiJ ENSTCUG00005005471
 protein coding gene Chr2:109744601-109790315 (-)
CBA/J ENSMUSG00210037110
 protein coding gene Chr2:110634619-110680231 (-)
DBA/2J ENSMUSG00185038583
 protein coding gene Chr2:110357032-110402636 (-)
FVB/NJ ENSMUSG00205013245
 protein coding gene Chr2:109615678-109661259 (-)
JF1/MsJ ENSUMUG00000002810
 protein coding gene Chr2:110191725-110239668 (-)
LP/J ENSMUSG00230004268
 protein coding gene Chr2:112156711-112209459 (-)
NOD/ShiLtJ ENSMUSG00190015166
 protein coding gene Chr2:110595645-110641222 (-)
NZO/HlLtJ ENSMUSG00225012770
 protein coding gene Chr2:120053209-120098813 (-)
PWK/PhJ ENSLUMG00010002879
 protein coding gene Chr2:110115540-110164093 (-)
SPRET/EiJ ENSMSPG00010031444
 protein coding gene Chr2:112373107-112418600 (-)
WSB/EiJ ENSIUOG00005030533
 protein coding gene Chr2:110288575-110334296 (-)



Homology
more
  • Human Ortholog
    SCG5, secretogranin V
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCG5, secretogranin V
  • Synonyms
    7B2, P7B2, SGNE1, SgV
  • Links
    NCBI Gene ID: 6447
    UniProt: P05408

  • Chr Location
    15q13.3; chr15:32641385-32697098 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scg5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene often die before weaning and display a variety of metabolic defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    110
  • cDNA Data
    48
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20394 NCBI Gene Model | MGI Sequence Detail 52716 C57BL/6J ±  kb
    transcript NM_001420947 RefSeq | MGI Sequence Detail 2991 ZRU/MplStud  
    polypeptide P12961 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 49
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14385, MGD-MRK-14386, MGI:2138903
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory