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Apcs Gene Detail
Summary
  • Symbol
    Apcs
  • Name
    amyloid P component, serum
  • Synonyms
    Sap
  • Feature Type
    protein coding gene
  • IDs
    MGI:98229
    NCBI Gene: 20219
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172721528-172722516 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98229
 protein coding gene Chr1:172721528-172722608 (-)
129S1/SvImJ ENSMUSG00200043839
 protein coding gene Chr1:170660867-170661947 (-)
A/J ENSMUSG00195048405
 protein coding gene Chr1:169963533-169964613 (-)
AKR/J ENSMUSG00220028683
 protein coding gene Chr1:169691589-169692669 (-)
BALB/cJ ENSMUSG00180039421
 protein coding gene Chr1:170289581-170290661 (-)
C3H/HeJ ENSMUSG00175042796
 protein coding gene Chr1:170300484-170301564 (-)
C57BL/6NJ ENSMUSG00215042370
 protein coding gene Chr1:169681766-169682846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014905
 protein coding gene Chr1:163145351-163146431 (-)
CAST/EiJ ENSTCUG00005044388
 protein coding gene Chr1:168236835-168237915 (-)
CBA/J ENSMUSG00210041332
 protein coding gene Chr1:170168538-170169618 (-)
DBA/2J ENSMUSG00185028857
 protein coding gene Chr1:174470670-174471750 (-)
FVB/NJ ENSMUSG00205025300
 protein coding gene Chr1:169154609-169155689 (-)
JF1/MsJ ENSUMUG00000008571
 protein coding gene Chr1:173395847-173396927 (-)
LP/J ENSMUSG00230027295
 protein coding gene Chr1:174065529-174066796 (-)
NOD/ShiLtJ ENSMUSG00190030742
 protein coding gene Chr1:169975940-169977020 (-)
NZO/HlLtJ ENSMUSG00225004834
 protein coding gene Chr1:177644411-177645687 (-)
PWK/PhJ ENSLUMG00010027281
 protein coding gene Chr1:168924214-168925294 (-)
SPRET/EiJ ENSMSPG00010046128
 protein coding gene Chr1:172288744-172289824 (-)
WSB/EiJ ENSIUOG00005034144
 protein coding gene Chr1:169303730-169304810 (-)



Homology
more
  • Human Ortholog
    APCS, amyloid P component, serum
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APCS, amyloid P component, serum
  • Synonyms
    HEL-S-92n, PTX2, SAP
  • Links
    NCBI Gene ID: 325
    UniProt: P02743

  • Chr Location
    1q23.2; chr1:159587826-159588865 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human APCS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased antibody productions, increased autoimmune antibodies, reduced amyloidosis and glomerulonephrosis depending on strain background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    3
  • cDNA Data
    34
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20219 NCBI Gene Model | MGI Sequence Detail 989 C57BL/6J ±  kb
    transcript NM_011318 RefSeq | MGI Sequence Detail 879 ZRU/MplStud  
    polypeptide P12246 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 27
      cDNA 34
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14288
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:8069 Mortensen RF, et al., Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. Immunogenetics. 1985;22(4):367-75
    • Latest
      J:377488 Bellissimo CJ, et al., Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation. Biol Reprod. 2025 Dec 16;113(6):1490-1509
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory