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Rpl12 Gene Detail
Summary
  • Symbol
    Rpl12
  • Name
    ribosomal protein L12
  • Feature Type
    protein coding gene
  • IDs
    MGI:98002
    NCBI Gene: 269261
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32851724-32854057 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98002
 protein coding gene Chr2:32851571-32855357 (+)
129S1/SvImJ ENSMUSG00200049733
 protein coding gene Chr2:29823994-29826931 (+)
A/J ENSMUSG00195046988
 protein coding gene Chr2:29927595-29930532 (+)
AKR/J ENSMUSG00220049754
 protein coding gene Chr2:30045513-30048450 (+)
BALB/cJ ENSMUSG00180053408
 protein coding gene Chr2:29940278-29943215 (+)
C3H/HeJ ENSMUSG00175052476
 protein coding gene Chr2:29906671-29909608 (+)
C57BL/6NJ ENSMUSG00215045941
 protein coding gene Chr2:29972177-29975114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023455
 protein coding gene Chr2:28847431-28851265 (+)
CAST/EiJ ENSTCUG00005053162
 protein coding gene Chr2:29653364-29656301 (+)
CBA/J ENSMUSG00210016479
 protein coding gene Chr2:29979211-29982148 (+)
DBA/2J ENSMUSG00185046672
 protein coding gene Chr2:29840832-29843769 (+)
FVB/NJ ENSMUSG00205037879
 protein coding gene Chr2:29687593-29690530 (+)
JF1/MsJ ENSUMUG00000045432
 protein coding gene Chr2:29728480-29731406 (+)
LP/J ENSMUSG00230042590
 protein coding gene Chr2:31759503-31762440 (+)
NOD/ShiLtJ ENSMUSG00190038198
 protein coding gene Chr2:29941944-29944881 (+)
NZO/HlLtJ ENSMUSG00225008562
 protein coding gene Chr2:39513334-39516271 (+)
PWK/PhJ ENSLUMG00010049101
 protein coding gene Chr2:29821842-29824779 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RPL12, ribosomal protein L12
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL12, ribosomal protein L12
  • Synonyms
    L12, uL11
  • Links
    NCBI Gene ID: 6136
    UniProt: P30050

  • Chr Location
    9q33.3; chr9:127447422-127451446 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RPL12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    3
  • cDNA Data
    22
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269261 NCBI Gene Model | MGI Sequence Detail 2334 C57BL/6J ±  kb
    transcript NM_009076 RefSeq | MGI Sequence Detail 643 C57BL/6  
    polypeptide P35979 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000014191 eukaryotic-type large ribosomal subunit protein uL11
      (term hierarchy)
    • PDB
      1WIB, 7LS1, 7LS2
    • InterPro Domains
      IPR020785 Large ribosomal subunit protein uL11, conserved site
      IPR020783 Large ribosomal subunit protein uL11, C-terminal
      IPR036769 Large ribosomal subunit protein uL11, C-terminal domain superfamily
      IPR020784 Large ribosomal subunit protein uL11, N-terminal
      IPR036796 Large ribosomal subunit protein uL11, N-terminal domain superfamily
      IPR000911 Ribosomal protein uL11
    • GlyGen
      P35979 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-14025
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 11
    • Earliest
      J:14408 Hou EW, et al., Sequence analysis of mouse cDNAs encoding ribosomal proteins L12 and L18. Gene. 1993 Aug 25;130(2):287-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory