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Rbp1 Gene Detail
Summary
  • Symbol
    Rbp1
  • Name
    retinol binding protein 1, cellular
  • Synonyms
    Crbp, CRBPI, Rbp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97876
    NCBI Gene: 19659
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98305014-98328604 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.36 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    826 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97876
 protein coding gene Chr9:98305014-98328628 (+)
129S1/SvImJ ENSMUSG00200016482
 protein coding gene Chr9:95432238-95455805 (+)
A/J ENSMUSG00195018128
 protein coding gene Chr9:94683443-94707014 (+)
AKR/J ENSMUSG00220037568
 protein coding gene Chr9:95057193-95080779 (+)
BALB/cJ ENSMUSG00180020437
 protein coding gene Chr9:95003083-95026654 (+)
C3H/HeJ ENSMUSG00175012525
 protein coding gene Chr9:95345940-95369505 (+)
C57BL/6NJ ENSMUSG00215021205
 protein coding gene Chr9:95322658-95346275 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032547
 protein coding gene Chr9:93993254-94016533 (+)
CAST/EiJ ENSTCUG00005012668
 protein coding gene Chr9:95163726-95187332 (+)
CBA/J ENSMUSG00210014586
 protein coding gene Chr9:95184251-95207820 (+)
DBA/2J ENSMUSG00185011417
 protein coding gene Chr9:95370611-95394178 (+)
FVB/NJ ENSMUSG00205014233
 protein coding gene Chr9:95376703-95400265 (+)
JF1/MsJ ENSUMUG00000020451
 protein coding gene Chr9:95127214-95150567 (+)
LP/J ENSMUSG00230016789
 protein coding gene Chr9:95538657-95562225 (+)
NOD/ShiLtJ ENSMUSG00190037199
 protein coding gene Chr9:95005839-95029406 (+)
NZO/HlLtJ ENSMUSG00225017877
 protein coding gene Chr9:95688480-95710425 (+)
PWK/PhJ ENSLUMG00010025439
 protein coding gene Chr9:95113485-95136818 (+)
SPRET/EiJ ENSMSPG00010003837
 protein coding gene Chr9:96913436-96935562 (+)
WSB/EiJ ENSIUOG00005023131
 protein coding gene Chr9:94441259-94464836 (+)



Homology
more
  • Human Ortholog
    RBP1, retinol binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBP1, retinol binding protein 1
  • Synonyms
    CRABP-I, CRBP, CRBP1, CRBPI, hCRBP1, RBPC
  • Links
    NCBI Gene ID: 5947
    UniProt: P09455

  • Chr Location
    3q23; chr3:139517434-139539829 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RBP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation show increased susceptibility to a diet deficient in vitamin A. Mutants also exhibit a two-fold delay in dark adaptation after a photic flash.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1072
  • Tissues
    287
  • cDNA Data
    90
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19659 NCBI Gene Model | MGI Sequence Detail 23591 C57BL/6J ±  kb
    transcript NM_011254 RefSeq | MGI Sequence Detail 2628 ZRU/MplStud  
    polypeptide Q00915 UniProt | EBI | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 2
      cDNA 96
      Primer pair 6
      Other 1
      Antibodies 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13787, MGD-MRK-13792, MGD-MRK-2131
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 60
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory