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Prl Gene Detail
Summary
  • Symbol
    Prl
  • Name
    prolactin
  • Synonyms
    Prl1a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97762
    NCBI Gene: 19109
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:27241553-27249187 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 12.25 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97762
 protein coding gene Chr13:27241553-27249188 (+)
129S1/SvImJ ENSMUSG00200028559
 protein coding gene Chr13:24401246-24408881 (+)
A/J ENSMUSG00195036146
 protein coding gene Chr13:23539405-23547040 (+)
AKR/J ENSMUSG00220012532
 protein coding gene Chr13:23348953-23356590 (+)
BALB/cJ ENSMUSG00180021209
 protein coding gene Chr13:23844662-23852297 (+)
C3H/HeJ ENSMUSG00175029461
 protein coding gene Chr13:23867358-23874991 (+)
C57BL/6NJ ENSMUSG00215008489
 protein coding gene Chr13:24006318-24013953 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018362
 protein coding gene Chr13:22755437-22763086 (+)
CAST/EiJ ENSTCUG00005009364
 protein coding gene Chr13:24030347-24037979 (+)
CBA/J ENSMUSG00210026475
 protein coding gene Chr13:23811611-23819246 (+)
DBA/2J ENSMUSG00185018847
 protein coding gene Chr13:24633560-24641195 (+)
FVB/NJ ENSMUSG00205024401
 protein coding gene Chr13:23631975-23639618 (+)
JF1/MsJ ENSUMUG00000014500
 protein coding gene Chr13:24285688-24293354 (+)
LP/J ENSMUSG00230018297
 protein coding gene Chr13:33954959-33962596 (+)
NOD/ShiLtJ ENSMUSG00190030647
 protein coding gene Chr13:23615654-23623291 (+)
NZO/HlLtJ ENSMUSG00225044273
 protein coding gene Chr13:27741159-27748794 (+)
PWK/PhJ ENSLUMG00010028806
 protein coding gene Chr13:23131726-23139358 (+)
SPRET/EiJ ENSMSPG00010023840
 protein coding gene Chr13:23067355-23075426 (+)
WSB/EiJ ENSIUOG00005015979
 protein coding gene Chr13:23188572-23196203 (+)



Homology
more
  • Human Ortholog
    PRL, prolactin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRL, prolactin
  • Synonyms
    GHA1, pPRL
  • Links
    NCBI Gene ID: 5617
    UniProt: P01236

  • Chr Location
    6p22.3; chr6:22287244-22302835 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PRL associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null female mice have irregular oestrus cycles and are infertile. Defects of the pituitary gland include hyperplasia, which progresses to adenoma, and impaired secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    36
  • cDNA Data
    1364
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19109 NCBI Gene Model | MGI Sequence Detail 7635 C57BL/6J ±  kb
    transcript NM_011164 RefSeq | MGI Sequence Detail 895 ZRU/MplStud  
    polypeptide P06879 UniProt | EBI | MGI Sequence Detail 226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1374
      Genomic 1
      cDNA 1364
      Primer pair 6
      Other 3
      Antibodies 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13613, MGI:2145398
    References
    more
    • Summaries
      All 239
      Developmental Gene Expression 87
      Gene Ontology 14
      Phenotypes 44
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:388801 Das P, et al., NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary. Endocrinology. 2026 May 26;167(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory