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Pgk1 Gene Detail
Summary
  • Symbol
    Pgk1
  • Name
    phosphoglycerate kinase 1
  • Synonyms
    Pgk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97555
    NCBI Gene: 18655
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:105230706-105247305 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.36 cM, cytoband C-D
  • Mapping Data
    62 experiments
Strain
Comparison
more
  • SNPs within 2kb
    373 from dbSNP Build 142
  • Strain Annotations
    36
  • PCR
    2
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97555
 protein coding gene ChrX:105230706-105247305 (+)
129S1/SvImJ ENSMUSG00200023129
 protein coding gene Chr12:7936779-7938541 (-)
129S1/SvImJ ENSMUSG00200037544
 protein coding gene ChrX:87014011-87030636 (+)
A/J ENSMUSG00195037835
 protein coding gene ChrX:90744407-90761024 (+)
A/J ENSMUSG00195014562
 protein coding gene Chr12:7980997-7982759 (-)
AKR/J ENSMUSG00220035345
 protein coding gene ChrX:85449435-85466063 (+)
AKR/J ENSMUSG00220027737
 protein coding gene Chr3:54851044-54853016 (-)
AKR/J ENSMUSG00220010814
 protein coding gene Chr10:25288443-25290162 (+)
BALB/cJ ENSMUSG00180015112
 protein coding gene Chr12:7973482-7975244 (-)
BALB/cJ ENSMUSG00180040119
 protein coding gene ChrX:87410523-87427142 (+)
C3H/HeJ ENSMUSG00175008524
 protein coding gene Chr3:54719013-54720902 (-)
C3H/HeJ ENSMUSG00175025044
 protein coding gene Chr10:25451772-25453491 (+)
C3H/HeJ ENSMUSG00175040971
 protein coding gene ChrX:90986381-91002993 (+)
C57BL/6NJ ENSMUSG00215045932
 protein coding gene ChrX:87639848-87656449 (+)
C57BL/6NJ ENSMUSG00215010886
 protein coding gene Chr12:7789660-7791422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033328
 protein coding gene ChrX:100209354-100225468 (+)
CAST/EiJ ENSTCUG00005039288
 protein coding gene ChrX:88435621-88452324 (+)
CBA/J ENSMUSG00210041959
 protein coding gene ChrX:87879976-87896603 (+)
CBA/J ENSMUSG00210003394
 protein coding gene Chr3:54834735-54836624 (-)
CBA/J ENSMUSG00210023249
 protein coding gene Chr10:25379696-25381415 (+)
DBA/2J ENSMUSG00185043282
 protein coding gene ChrX:100334427-100351043 (+)
DBA/2J ENSMUSG00185020316
 protein coding gene Chr12:7968946-7970706 (-)
DBA/2J ENSMUSG00185007029
 protein coding gene Chr10:25551842-25553561 (+)
FVB/NJ ENSMUSG00205028253
 protein coding gene ChrX:86956348-86972964 (+)
FVB/NJ ENSMUSG00205009850
 protein coding gene Chr10:25554279-25555998 (+)
JF1/MsJ ENSUMUG00000036821
 protein coding gene ChrX:120940935-120957954 (+)
LP/J ENSMUSG00230004421
 protein coding gene Chr3:57017845-57019707 (-)
LP/J ENSMUSG00230041343
 protein coding gene ChrX:107011393-107028017 (+)
NOD/ShiLtJ ENSMUSG00190034063
 protein coding gene ChrX:87070836-87087460 (+)
NOD/ShiLtJ ENSMUSG00190007883
 protein coding gene Chr12:9220489-9222251 (-)
NZO/HlLtJ ENSMUSG00225015638
 protein coding gene Chr3:59630368-59632190 (-)
NZO/HlLtJ ENSMUSG00225029382
 protein coding gene Chr12:11868727-11870489 (-)
NZO/HlLtJ ENSMUSG00225039872
 protein coding gene ChrX:112145078-112161697 (+)
PWK/PhJ ENSLUMG00010036873
 protein coding gene ChrX:86198971-86215979 (+)
SPRET/EiJ ENSMSPG00010036377
 protein coding gene ChrX:90448820-90465427 (+)
WSB/EiJ ENSIUOG00005040350
 protein coding gene ChrX:87581240-87597853 (+)



Homology
more
  • Human Ortholog
    PGK1, phosphoglycerate kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGK1, phosphoglycerate kinase 1
  • Synonyms
    HEL-S-68p, MIG10, PGKA
  • Links
    NCBI Gene ID: 5230
    UniProt: P00558

  • Chr Location
    Xq21.1; chrX:77910739-78129295 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PGK1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1019
  • Tissues
    229
  • cDNA Data
    21
  • Literature Summary
    63
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18655 NCBI Gene Model | MGI Sequence Detail 16600 C57BL/6J ±  kb
transcript NM_008828 RefSeq | MGI Sequence Detail 1840 C57BL/6  
polypeptide P09411 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    Genomic 19
    cDNA 26
    Primer pair 9
    Other 6
    Antibodies 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13258, MGD-MRK-13266
References
more
  • Summaries
    All 209
    Developmental Gene Expression 63
    Gene Ontology 23
    Phenotypes 8
  • Earliest
    J:320603 Crisp DM, et al., Glycolytic and gluconeogenic enzyme activities in parenchymal and non-parenchymal cells from mouse liver. Biochem J. 1972 Feb;126(4):1009-23
  • Latest
    J:391120 Ma Z, et al., PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity. Cell Rep. 2025 Jun 24;44(6):115785
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory