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Pcmt1 Gene Detail
Summary
  • Symbol
    Pcmt1
  • Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
  • Synonyms
    PIMT, protein carboxyl methyltransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97502
    NCBI Gene: 18537
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:7505137-7556900 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.26 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1272 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97502
 protein coding gene Chr10:7503608-7556922 (-)
129S1/SvImJ ENSMUSG00200008946
 protein coding gene Chr10:4500122-4551346 (-)
A/J ENSMUSG00195008559
 protein coding gene Chr10:4388876-4440103 (-)
AKR/J ENSMUSG00220007053
 protein coding gene Chr10:4507194-4558423 (-)
BALB/cJ ENSMUSG00180020650
 protein coding gene Chr10:4550975-4602200 (-)
C3H/HeJ ENSMUSG00175012206
 protein coding gene Chr10:4542722-4592184 (-)
C57BL/6NJ ENSMUSG00215004908
 protein coding gene Chr10:4443329-4495096 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015098
 protein coding gene Chr10:4200142-4250152 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210012463
 protein coding gene Chr10:4488505-4537964 (-)
DBA/2J ENSMUSG00185009321
 protein coding gene Chr10:4534912-4584371 (-)
FVB/NJ ENSMUSG00205008276
 protein coding gene Chr10:4487934-4537393 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230013872
 protein coding gene Chr10:6149927-6201144 (-)
NOD/ShiLtJ ENSMUSG00190022345
 protein coding gene Chr10:4479689-4529142 (-)
NZO/HlLtJ ENSMUSG00225015882
 protein coding gene Chr10:10672933-10722380 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PCMT1, protein-L-isoaspartate (D-aspartate) O-methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCMT1, protein-L-isoaspartate (D-aspartate) O-methyltransferase
  • Synonyms
    PIMT
  • Links
    NCBI Gene ID: 5110
    UniProt: P22061

  • Chr Location
    6q25.1; chr6:149749431-149811421 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene causes accumulation of modified proteins, growth retardation and fatal epileptic seizures. Homozygotes for one null allele also show a small spleen, altered lipid, hormone, mineral and enzyme profiles, kyphosis, enlarged brain and abnormal dendritic arborizations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019795 Ensembl Gene Model | MGI Sequence Detail 51764 C57BL/6J ±  kb
    transcript ENSMUST00000162606 Ensembl | MGI Sequence Detail 2757 Not Applicable  
    polypeptide ENSMUSP00000123866 Ensembl | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000012420 protein-L-isoaspartate(D-aspartate) O-methyltransferase
      (term hierarchy)
    • EC
      2.1.1.77
    • InterPro Domains
      IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    • GlyGen
      P23506 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 7
      cDNA 21
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-13176, MGI:2143926
    References
    more
    • Summaries
      All 72
      Gene Ontology 10
      Phenotypes 34
    • Earliest
      J:2260 Romanik EA, et al., Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase. Gene. 1992 Sep 10;118(2):217-22
    • Latest
      J:385706 Kalailingam P, et al., Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation. Aging Cell. 2025 Apr;24(4):e14425
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory