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Nppa Gene Detail
Summary
  • Symbol
    Nppa
  • Name
    natriuretic peptide type A
  • Synonyms
    Anf, ANP, atrial natriuretic peptide, natriuretic peptide precursor A, Pnd
  • Feature Type
    protein coding gene
  • IDs
    MGI:97367
    NCBI Gene: 230899
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148085179-148086531 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.66 cM
  • Mapping Data
    61 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    6
  • RFLP
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97367
 protein coding gene Chr4:148085179-148086536 (+)
129S1/SvImJ ENSMUSG00200044201
 protein coding gene Chr4:139118945-139120304 (+)
A/J ENSMUSG00195030382
 protein coding gene Chr4:140778927-140780284 (+)
AKR/J ENSMUSG00220045640
 protein coding gene Chr4:140354866-140356225 (+)
BALB/cJ ENSMUSG00180040706
 protein coding gene Chr4:138461604-138462961 (+)
C3H/HeJ ENSMUSG00175033344
 protein coding gene Chr4:141735400-141736759 (+)
C57BL/6NJ ENSMUSG00215046855
 protein coding gene Chr4:140585224-140586581 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026789
 protein coding gene Chr4:137841487-137842842 (+)
CAST/EiJ ENSTCUG00005029065
 protein coding gene Chr4:144411749-144413109 (+)
CBA/J ENSMUSG00210027399
 protein coding gene Chr4:140387102-140388461 (+)
DBA/2J ENSMUSG00185014698
 protein coding gene Chr4:143948656-143950015 (+)
FVB/NJ ENSMUSG00205035840
 protein coding gene Chr4:138854783-138856140 (+)
JF1/MsJ ENSUMUG00000003266
 protein coding gene Chr4:146977758-146979123 (+)
LP/J ENSMUSG00230013938
 protein coding gene Chr4:150690528-150691887 (+)
NOD/ShiLtJ ENSMUSG00190020397
 protein coding gene Chr4:140056993-140058351 (+)
NZO/HlLtJ ENSMUSG00225024380
 protein coding gene Chr4:154684379-154685736 (+)
PWK/PhJ ENSLUMG00010037616
 protein coding gene Chr4:139246693-139248051 (+)
SPRET/EiJ ENSMSPG00010025737
 protein coding gene Chr4:141188812-141190170 (+)
WSB/EiJ ENSIUOG00005042949
 protein coding gene Chr4:138227465-138228822 (+)



Homology
more
  • Human Ortholog
    NPPA, natriuretic peptide A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPPA, natriuretic peptide A
  • Synonyms
    ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND
  • Links
    NCBI Gene ID: 4878
    UniProt: P01160

  • Chr Location
    1p36.22; chr1:11845709-11848345 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nppa mouse models; 7 with human NPPA associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes are chronically hypertensive partly due to changes in peripheral resistance and increased central AT1-receptor activation, and show salt-sensitive hypertension and abnormal pulmonary vascular remodeling with increased ventricular mass and muscularization of peripheral pulmonary vessels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1027
  • Tissues
    123
  • cDNA Data
    96
  • Literature Summary
    312
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230899 NCBI Gene Model | MGI Sequence Detail 1353 C57BL/6J ±  kb
    transcript NM_008725 RefSeq | MGI Sequence Detail 860 ZRU/MplStud  
    polypeptide P05125 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      Genomic 8
      cDNA 102
      Primer pair 47
      Other 40
      Antibodies 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12921, MGD-MRK-1319, MGD-MRK-13536
    References
    more
    • Summaries
      All 496
      Developmental Gene Expression 312
      Diseases 1
      Gene Ontology 17
      Phenotypes 48
    • Earliest
      J:7667 Seidman CE, et al., Nucleotide sequences of the human and mouse atrial natriuretic factor genes. Science. 1984 Dec 7;226(4679):1206-9
    • Latest
      J:374945 Li X, et al., Vinculin Y822 phosphorylation regulates adhesion remodeling during cardiomyocyte maturation. J Cell Sci. 2025 Nov 13;:jcs.263984
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory