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Neu1 Gene Detail
Summary
  • Symbol
    Neu1
  • Name
    neuraminidase 1
  • Synonyms
    Aglp, Apl, Bat-7, Bat7, G9, lysosomal sialidase, Map-2, Neu-1, sialidase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97305
    NCBI Gene: 18010
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35150229-35154929 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.48 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97305
 protein coding gene Chr17:35150229-35156273 (+)
129S1/SvImJ ENSMUSG00200048642
 protein coding gene Chr17:30854337-30859005 (+)
A/J ENSMUSG00195041516
 protein coding gene Chr17:31754494-31759162 (+)
AKR/J ENSMUSG00220049694
 protein coding gene Chr17:30783182-30787850 (+)
BALB/cJ ENSMUSG00180039753
 protein coding gene Chr17:31124370-31129038 (+)
C3H/HeJ ENSMUSG00175034685
 protein coding gene Chr17:30669299-30673967 (+)
C57BL/6NJ ENSMUSG00215051000
 protein coding gene Chr17:30694532-30699199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021485
 protein coding gene Chr17:31671253-31676341 (+)
CAST/EiJ ENSTCUG00005048519
 protein coding gene Chr17:31712975-31717651 (+)
CBA/J ENSMUSG00210047102
 protein coding gene Chr17:30491407-30496075 (+)
DBA/2J ENSMUSG00185051237
 protein coding gene Chr17:33143610-33148278 (+)
FVB/NJ ENSMUSG00205052504
 protein coding gene Chr17:31013156-31017823 (+)
JF1/MsJ ENSUMUG00000050578
 protein coding gene Chr17:32396687-32401354 (+)
LP/J ENSMUSG00230054581
 protein coding gene Chr17:34252599-34257267 (+)
NOD/ShiLtJ ENSMUSG00190042420
 protein coding gene Chr17:30614126-30618788 (+)
NZO/HlLtJ ENSMUSG00225054202
 protein coding gene Chr17:36265756-36270423 (+)
PWK/PhJ ENSLUMG00010039314
 protein coding gene Chr17:30231230-30235893 (+)
SPRET/EiJ ENSMSPG00010048908
 protein coding gene Chr17:31417521-31423360 (+)
WSB/EiJ ENSIUOG00005049980
 protein coding gene Chr17:31341749-31346403 (+)



Homology
more
  • Human Ortholog
    NEU1, neuraminidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEU1, neuraminidase 1
  • Synonyms
    NANH, NEU, SIAL1
  • Links
    NCBI Gene ID: 4758
    UniProt: Q99519

  • Chr Location
    6p21.33; chr6:31857063-31862905 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Neu1 mouse models; 1 with human NEU1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 3 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice develop features of early-onset lysosomal storage disease (sialidosis), including severe nephropathy, edema, splenomegaly, kyphosis and oligosacchariduria, and display myoclonus, lordosis, extramedullary hematopoiesis, dyspnea, weight loss, gait defects, tremors and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    102
  • cDNA Data
    170
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007038 Ensembl Gene Model | MGI Sequence Detail 4701 C57BL/6J ±  kb
    transcript ENSMUST00000007253 Ensembl | MGI Sequence Detail 2474 Not Applicable  
    polypeptide ENSMUSP00000007253 Ensembl | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      Genomic 3
      cDNA 171
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1182, MGD-MRK-12114, MGD-MRK-12819, MGD-MRK-12820, MGD-MRK-1358, MGD-MRK-1504, MGD-MRK-1512, MGI:2146738, MGI:2146740, MGI:88131
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:4457 Lalley PA, et al., Lysosomal Acid Phosphatase Deficiency: Liver Specific Variant in the Mouse. Genetics. 1977 Oct;87(2):305-317
    • Latest
      J:387988 Viana GM, et al., Cathepsin B inhibition blocks amyloidogenesis in the mouse models of neurological lysosomal diseases MPS IIIC and sialidosis. Mol Ther Methods Clin Dev. 2025 Mar 13;33(1):101432
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory