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Mt3 Gene Detail
Summary
  • Symbol
    Mt3
  • Name
    metallothionein 3
  • Synonyms
    MT-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97173
    NCBI Gene: 17751
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94879235-94880774 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    14
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97173
 protein coding gene Chr8:94879235-94880776 (+)
129S1/SvImJ ENSMUSG00200016900
 protein coding gene Chr8:89239395-89240938 (+)
A/J ENSMUSG00195027245
 protein coding gene Chr8:89601959-89603503 (+)
AKR/J ENSMUSG00220039140
 protein coding gene Chr8:89629034-89630582 (+)
BALB/cJ ENSMUSG00180021783
 protein coding gene Chr8:89485827-89487370 (+)
C3H/HeJ ENSMUSG00175025930
 protein coding gene Chr8:89545162-89546704 (+)
C57BL/6NJ ENSMUSG00215013382
 protein coding gene Chr8:89150504-89152044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031392
 protein coding gene Chr8:85642277-85643817 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210032662
 protein coding gene Chr8:89479645-89481186 (+)
DBA/2J ENSMUSG00185022768
 protein coding gene Chr8:95588473-95590014 (+)
FVB/NJ ENSMUSG00205015554
 protein coding gene Chr8:88573221-88574762 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230025765
 protein coding gene Chr8:99233137-99234679 (+)
NOD/ShiLtJ ENSMUSG00190013871
 protein coding gene Chr8:89606585-89608145 (+)
NZO/HlLtJ ENSMUSG00225009380
 protein coding gene Chr8:102629118-102630663 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MT3, metallothionein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MT3, metallothionein 3
  • Synonyms
    GIF, GIFB, GRIF, ZnMT3
  • Links
    NCBI Gene ID: 4504
    UniProt: P25713

  • Chr Location
    16q13; chr16:56589074-56591088 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MT3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a zinc deficiency in several brain regions, abnormal astrocyte morphology, increased susceptibility to kainic acid induced seizures, and altered zinc accumulation and neuronal death in certain brain areas following seizure-induced or acute brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    105
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    36
  • cDNA Data
    38
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031760 Ensembl Gene Model | MGI Sequence Detail 1540 C57BL/6J ±  kb
    transcript ENSMUST00000211930 Ensembl | MGI Sequence Detail 477 Not Applicable  
    polypeptide ENSMUSP00000148345 Ensembl | MGI Sequence Detail 80 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 2
      cDNA 38
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12575, MGD-MRK-12578
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 9
      Gene Ontology 14
      Phenotypes 20
    • Earliest
      J:1500 Palmiter RD, et al., MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6333-7
    • Latest
      J:389383 Lee HS, et al., Zinc-Mediated Lysosomal Destabilization Links Mitochondrial Damage to Neuronal Death in a Cellular MPP(+) Model of Parkinson's Disease. J Neurochem. 2026 Feb;170(2):e70363
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory