Il7r MGI Mouse Gene Detail - MGI:96562

Symbol

Il7r
Name

interleukin 7 receptor
Synonyms

CD127, IL-7Ralpha, IL-7 receptor alpha chain

Feature Type

protein coding gene
IDs

MGI:96562
NCBI Gene: 16197
Alliance

genome feature page
Transcription Start Sites

18 TSS
Regulated by

Rr586, Rr186, Rr170 (3 regulatory regions)

Sequence Map

Chr15:9505874-9530262 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 4.16 cM
Mapping Data

6 experiments

SNPs within 2kb

745 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96562	protein coding gene	Chr15:9505874-9530270 (-)
129S1/SvImJ	ENSMUSG00200033319	protein coding gene	Chr15:6486224-6510267 (-)
A/J	ENSMUSG00195010015	protein coding gene	Chr15:6383832-6407877 (-)
AKR/J	ENSMUSG00220022196	protein coding gene	Chr15:6328919-6352852 (-)
BALB/cJ	ENSMUSG00180032873	protein coding gene	Chr15:6395914-6419968 (-)
C3H/HeJ	ENSMUSG00175031784	protein coding gene	Chr15:6553335-6577375 (-)
C57BL/6NJ	ENSMUSG00215019003	protein coding gene	Chr15:6433568-6457622 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019659	protein coding gene	Chr15:5940975-5964569 (-)
CAST/EiJ	ENSTCUG00005024535	protein coding gene	Chr15:6511526-6535369 (-)
CBA/J	ENSMUSG00210025141	protein coding gene	Chr15:6538379-6562428 (-)
DBA/2J	ENSMUSG00185030909	protein coding gene	Chr15:6495312-6519367 (-)
FVB/NJ	ENSMUSG00205026679	protein coding gene	Chr15:6376602-6400641 (-)
JF1/MsJ	ENSUMUG00000032414	protein coding gene	Chr15:6599699-6623566 (-)
LP/J	ENSMUSG00230017633	protein coding gene	Chr15:9979241-10003287 (-)
NOD/ShiLtJ	ENSMUSG00190009637	protein coding gene	Chr15:6454612-6478649 (-)
NZO/HlLtJ	ENSMUSG00225024038	protein coding gene	Chr15:10215670-10239703 (-)
PWK/PhJ	ENSLUMG00010033127	protein coding gene	Chr15:6651453-6675230 (-)
SPRET/EiJ	ENSMSPG00010031467	protein coding gene	Chr15:6638179-6661932 (-)
WSB/EiJ	ENSIUOG00005027628	protein coding gene	Chr15:6452907-6476858 (-)

Human Ortholog

IL7R, interleukin 7 receptor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL7R, interleukin 7 receptor
Synonyms

CD127, CDW127, IL7RA, IL-7R-alpha, IL-7Ralpha, IL7Ralpha, ILRA, IMD104, lnc-IL7R, sIL-7R
Links

HGNC:6024

NCBI Gene ID: 3575

UniProt: P16871
Chr Location

5p13.2; chr5:35852695-35879603 (+) GRCh38

MGI Vertebrate Homology

Il7r stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL7R
Gene Tree

Il7r

Diseases

5 with human IL7R associations

				Human Disease	Mouse Models
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				severe combined immunodeficiency IDs severe combined immunodeficiency DOID:627 MESH:D016511 NCI:C3472 UMLS_CUI:C0085110
				severe combined immunodeficiency 104 IDs severe combined immunodeficiency 104 DOID:0090014 ICD10CM:D81.2 MESH:C563822 OMIM:608971 ORDO:169154
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C194067 NCI:C194069 NCI:C194070 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

40 phenotypes from 7 alleles in 10 genetic backgrounds
6 phenotypes from multigenic genotypes
291 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

17
Targeted

10
Transgenic

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutations cause arrested T and B cell differentiation and severely reduced thymus and spleen cellularity. Mice homozygous for a knock-in allele show partial rescue of T cell numbers during late thymus development, and impaired CD8 T cell memory and CD4 T cell primary responses.

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All GO Annotations

45
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

638
Tissues

25
cDNA Data

144
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il7r

ZFIN il7r

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All Sequences

52
RefSeq

9
UniProt

5
CCDS

CCDS27376.1, CCDS88732.1

Ensembl

ENSMUSG00000003882 (Evidence)
NCBI Gene

16197

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003882	Ensembl Gene Model \| MGI Sequence Detail	24389	C57BL/6J	± kb
transcript	ENSMUST00000003981	Ensembl \| MGI Sequence Detail	3540	Not Applicable
polypeptide	ENSMUSP00000003981	Ensembl \| MGI Sequence Detail	459	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001869 interleukin-7 receptor subunit alpha

(term hierarchy)
PDB

4NN5, 4NN6, 4NN7, 5J12, 8DDC
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR040997 IL-7Ralpha, fibronectin type III domain

IPR013783 Immunoglobulin-like fold

IPR003531 Short hematopoietin receptor, family 1, conserved site
GlyGen

P16872 3 sites

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All nucleic 158

Genomic 4

cDNA 147

Primer pair 7

Antibodies 1

Microarray probesets 4

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MGD-MRK-11395

Summaries

All 425

Developmental Gene Expression 25

Gene Ontology 14

Phenotypes 291
Earliest

J:10373 Goodwin RG, et al., Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990 Mar 23;60(6):941-51
Latest

J:391848 Jones Iv AR, et al., Cell-intrinsic IL-7Ralpha deficiency in Foxp3+ Tregs increases type 1 diabetes incidence in NOD mice. Immunohorizons. 2026 Aug 4;10(8)

Il7r expression regulated by:

Feature	Feature Type	Location	Reference
Rr586, regulatory region 586	enhancer	Chr15:9524195-9524344	J:359660
Rr186, regulatory region 186	promoter	Chr15:9529826-9530198	J:100878
Rr170, regulatory region 170	enhancer	Chr15:9533370-9533783	J:100878

TSS for Il7r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133710	Chr15:9530397-9530408 (-)	-141 bp
Tssr133709	Chr15:9530220-9530271 (-)	16 bp
Tssr133708	Chr15:9530118-9530122 (-)	142 bp
Tssr133707	Chr15:9529954-9529967 (-)	301 bp
Tssr133706	Chr15:9529936-9529951 (-)	318 bp
Tssr133705	Chr15:9529899-9529932 (-)	346 bp
Tssr133704	Chr15:9529824-9529858 (-)	421 bp
Tssr133703	Chr15:9529783-9529794 (-)	473 bp
Tssr133702	Chr15:9528164-9528174 (-)	2,093 bp
Tssr133701	Chr15:9528129-9528138 (-)	2,128 bp
Tssr133700	Chr15:9524215-9524221 (-)	6,044 bp
Tssr133699	Chr15:9524178-9524190 (-)	6,078 bp
Tssr133698	Chr15:9516548-9516579 (-)	13,698 bp
Tssr133697	Chr15:9508843-9508872 (-)	21,404 bp
Tssr133696	Chr15:9507862-9507890 (-)	22,386 bp
Tssr133695	Chr15:9507522-9507534 (-)	22,734 bp
Tssr133694	Chr15:9507199-9507211 (-)	23,057 bp
Tssr133693	Chr15:9506836-9506848 (-)	23,420 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24