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Ide Gene Detail
Summary
  • Symbol
    Ide
  • Name
    insulin degrading enzyme
  • Synonyms
    1300012G03Rik, 4833415K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96412
    NCBI Gene: 15925
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:37246142-37340010 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.24 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2425 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96412
 protein coding gene Chr19:37246140-37341664 (-)
129S1/SvImJ ENSMUSG00200027583
 protein coding gene Chr19:34036964-34131080 (-)
A/J ENSMUSG00195010315
 protein coding gene Chr19:34135613-34230575 (-)
AKR/J ENSMUSG00220018374
 protein coding gene Chr19:34019453-34113568 (-)
BALB/cJ ENSMUSG00180027981
 protein coding gene Chr19:34464396-34558515 (-)
C3H/HeJ ENSMUSG00175034704
 protein coding gene Chr19:33898528-33992547 (-)
C57BL/6NJ ENSMUSG00215019843
 protein coding gene Chr19:33910650-34004814 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022912
 protein coding gene Chr19:33835286-33932058 (-)
CAST/EiJ ENSTCUG00005014934
 protein coding gene Chr19:33577817-33675704 (-)
CBA/J ENSMUSG00210035319
 protein coding gene Chr19:33977814-34071800 (-)
DBA/2J ENSMUSG00185031120
 protein coding gene Chr19:34498020-34592023 (-)
FVB/NJ ENSMUSG00205007299
 protein coding gene Chr19:33743189-33837353 (-)
JF1/MsJ ENSUMUG00000021896
 protein coding gene Chr19:34647975-34739775 (-)
LP/J ENSMUSG00230032139
 protein coding gene Chr19:35308834-35402947 (-)
NOD/ShiLtJ ENSMUSG00190009544
 protein coding gene Chr19:33874871-33968939 (-)
NZO/HlLtJ ENSMUSG00225029267
 protein coding gene Chr19:38858674-38952784 (-)
PWK/PhJ ENSLUMG00010000968
 protein coding gene Chr19:34031193-34122487 (-)
SPRET/EiJ ENSMSPG00010021549
 protein coding gene Chr19:33745360-33849380 (-)
WSB/EiJ ENSIUOG00005032829
 protein coding gene Chr19:33385876-33480093 (-)



Homology
more
  • Human Ortholog
    IDE, insulin degrading enzyme
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IDE, insulin degrading enzyme
  • Synonyms
    INSULYSIN
  • Links
    NCBI Gene ID: 3416
    UniProt: P14735

  • Chr Location
    10q23.33; chr10:92451684-92574096 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IDE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show beta amyloid accumulations in the brain, hyperinsulinemia, and glucose intolerance. Mice homozygous for a different null allele show decreased testis weight, small seminiferous tubules, abnormal sperm morphology, and decreased sperm viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1051
  • Tissues
    172
  • cDNA Data
    169
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      61
    • RefSeq
      14
    • UniProt
      4
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056999 Ensembl Gene Model | MGI Sequence Detail 93869 C57BL/6J ±  kb
    transcript ENSMUST00000131070 Ensembl | MGI Sequence Detail 5059 Not Applicable  
    polypeptide ENSMUSP00000121358 Ensembl | MGI Sequence Detail 1019 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 171
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11179, MGI:1914150, MGI:1921015, MGI:2147459, MGI:2147575
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 10
      Gene Ontology 16
      Phenotypes 26
    • Earliest
      J:11022 Affholter JA, et al., Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol. 1990 Aug;4(8):1125-35
    • Latest
      J:369570 Morito T, et al., The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease. J Neurosci. 2025 Jun 4;45(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory