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Hal Gene Detail
Summary
  • Symbol
    Hal
  • Name
    histidine ammonia lyase
  • Synonyms
    histidase, Hsd
  • Feature Type
    protein coding gene
  • IDs
    MGI:96010
    NCBI Gene: 15109
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:93324630-93352623 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 48.49 cM, cytoband C2-D1
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96010
 protein coding gene Chr10:93324630-93355166 (+)
129S1/SvImJ ENSMUSG00200026389
 protein coding gene Chr10:89837918-89868517 (+)
A/J ENSMUSG00195019748
 protein coding gene Chr10:90275692-90306301 (+)
AKR/J ENSMUSG00220020554
 protein coding gene Chr10:89843284-89873885 (+)
BALB/cJ ENSMUSG00180032313
 protein coding gene Chr10:90278433-90309039 (+)
C3H/HeJ ENSMUSG00175020993
 protein coding gene Chr10:90179246-90209845 (+)
C57BL/6NJ ENSMUSG00215012324
 protein coding gene Chr10:89854911-89885458 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015732
 protein coding gene Chr10:87202640-87231957 (+)
CAST/EiJ ENSTCUG00005034499
 protein coding gene Chr10:89555346-89586114 (+)
CBA/J ENSMUSG00210033540
 protein coding gene Chr10:90014357-90044958 (+)
DBA/2J ENSMUSG00185037891
 protein coding gene Chr10:90226232-90256920 (+)
FVB/NJ ENSMUSG00205018131
 protein coding gene Chr10:89928981-89959582 (+)
JF1/MsJ ENSUMUG00000025255
 protein coding gene Chr10:91634599-91665141 (+)
LP/J ENSMUSG00230019964
 protein coding gene Chr10:92134044-92162820 (+)
NOD/ShiLtJ ENSMUSG00190017758
 protein coding gene Chr10:90263679-90294274 (+)
NZO/HlLtJ ENSMUSG00225021287
 protein coding gene Chr10:96383362-96414825 (+)
PWK/PhJ ENSLUMG00010021851
 protein coding gene Chr10:89901259-89931884 (+)
SPRET/EiJ ENSMSPG00010010088
 protein coding gene Chr10:91516755-91544540 (+)
WSB/EiJ ENSIUOG00005033035
 protein coding gene Chr10:89958195-89989791 (+)



Homology
more
  • Human Ortholog
    HAL, histidine ammonia-lyase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAL, histidine ammonia-lyase
  • Synonyms
    HIS, HSTD
  • Links
    NCBI Gene ID: 3034
    UniProt: P42357

  • Chr Location
    12q23.1; chr12:95972662-95996365 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HAL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene cause elevated histidine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    55
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15109 NCBI Gene Model | MGI Sequence Detail 27994 C57BL/6J ±  kb
    transcript NM_010401 RefSeq | MGI Sequence Detail 2776 ZRU/MplStud  
    polypeptide P35492 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10611, MGD-MRK-10720, MGD-MRK-10944
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:5382 Kacser H, et al., Histidinaemic mutant in the mouse. Nature. 1973 Jul 13;244(5411):77-9
    • Latest
      J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory